Pharmacokinetic-Pharmacodynamic Modeling and Simulation

  • Peter L. Bonate

About this book

Introduction

This book presents both the art and science behind pharmacokinetic-pharmacodynamic modeling. Using a building-block approach, the author starts from linear and nonlinear models at the individual level and proceeds to develop more complex linear and nonlinear mixed effects models at the population level, with particular emphasis on showing the interrelationships between the various model types. The theory behind the methods are illustrated using real data drawn from the literature and from the author’s own experiences in drug development. Data are analyzed using a variety of software, including SAS, WinNonlin, SAAM II, and NONMEM. A key component of the book is to show how models are accepted and rejected, ultimately leading to a useful and informative model that can be utilized using computer simulation to answer "what-if" questions.

Keywords

development evolution pharmacodynamics pharmacokinetics population simulation

Authors and affiliations

  • Peter L. Bonate
    • 1
  1. 1.Genzyme OncologySan AntonioUSA

Bibliographic information

  • DOI https://doi.org/10.1007/b138744
  • Copyright Information Springer Science+Business Media, Inc. 2006
  • Publisher Name Springer, Boston, MA
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-0-387-27197-2
  • Online ISBN 978-0-387-27199-6
  • About this book