The Link Between Inflammation and Cancer

Wounds that do not heal

  • Angus G. Dalgleish
  • Burkhard Haefner
Part of the Cancer Treatment and Research book series (CTAR, volume 130)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Angus G. Dalgleish, Ken O’Byrne
    Pages 1-38
  3. Lindsey Jackson, B. Mark Evers
    Pages 39-65
  4. Arndt J. Schottelius, Harald Dinter
    Pages 67-87
  5. Linda Vermeulen, Wim Vanden Berghe, Guy Haegeman
    Pages 89-102
  6. Theresa L. Whiteside
    Pages 103-124
  7. Isaac P. Witz
    Pages 125-140
  8. Jessica Bertout, Andrei Thomas-Tikhonenko
    Pages 167-197
  9. Josep M. Argilés, Sílvia Busquets, Francisco J. López-Soriano
    Pages 199-217
  10. Back Matter
    Pages 247-254

About this book

Introduction

The transcription factor NF-kB has long been known to play a central role in the immune system by regulating the expression of key genes. Moreover, activation of this transcription factor helps a wide variety of cell types survive damage induced by pro-apoptotic stimuli. Owing to its critical role in the regulation of pro-inflammatory genes, NF-kB has long been regarded as a promising target for the discovery of anti-inflammatory drugs. More recently, NF-kB has emerged as a major culprit in a variety of human cancers mainly due to its ability to protect transformed cells from apoptosis. This finding should not have come as a surprise since there exists a link between inflammation and many types of cancer which was already suggested by Galen and later demonstrated by Virchow. This link, of crucial importance for the design of novel strategies for cancer treatment, is the topic of this book. 

Series Editor Cover Comments:

"Inflammation is a known risk factor for a number of cancers. In this text, experts discuss the pathophysiology and molecular alterations that link these two processes. Potential therapeutics and preventive strategies are discussed."

Steven T. Rosen, M.D.
Series Editor

Keywords

angiogenesis apoptosis cancer treatment cell cytokines pancreatic cancer pathogenesis tumor

Editors and affiliations

  • Angus G. Dalgleish
    • 1
  • Burkhard Haefner
    • 2
  1. 1.Division of OncologySt. George’s Hospital Medical SchoolLondonUK
  2. 2.Department of Oncology Johnson and Johnson PharmaceuticalResearch and DevelopmentBeerseBelgium

Bibliographic information

  • DOI https://doi.org/10.1007/b137303
  • Copyright Information Springer-Verlag US 2006
  • Publisher Name Springer, Boston, MA
  • eBook Packages Medicine
  • Print ISBN 978-0-387-26282-6
  • Online ISBN 978-0-387-26283-3
  • Series Print ISSN 0927-3042
  • About this book