Molecular Mechanisms of Synaptogenesis

  • Alexander Dityatev
  • Alaa El-Husseini

Table of contents

  1. Front Matter
    Pages i-xxvi
  2. Synaptogenesis: When Long-Distance Relations Become Intimate

  3. Experimental Models of Synaptogenesis

  4. Roles of Cell Adhesion and Secreted Molecules in Synaptic Differentiation

    1. Front Matter
      Pages 81-81
    2. Richard Fairless, Carsten Reissner, Markus Missler
      Pages 111-124
    3. Joshua A. Weiner
      Pages 137-150
    4. Yu Yamaguchi, Fumitoshi Irie
      Pages 151-161
    5. Erik M. Ullian, Alexander Dityatev
      Pages 163-178
    6. Newton H. Woo, Hyun-soo Je, Bai Lu
      Pages 179-194
  5. Transport of Synaptic Proteins

    1. Front Matter
      Pages 195-195
    2. Philip E. Washbourne
      Pages 209-220
    3. Laurent Groc, Martin Heine, Laurent Cognet, Brahim Lounis, Daniel Choquet
      Pages 221-232
  6. Synaptic Cytoskeleton and Morphogenic Signaling

    1. Front Matter
      Pages 233-233
    2. Thomas Dresbach, Anna Fejtová, Eckart D. Gundelfinger
      Pages 235-245
    3. Stefano Romorini, Giovanni Piccoli, Carlo Sala
      Pages 261-276
    4. Yunhee Kang, Ann Marie Craig
      Pages 277-295
    5. Jochen C. Meier
      Pages 311-332
    6. Imbritt König, Michael R. Kreutz
      Pages 333-346
  7. Synaptic Plasticity in Learning and Memory

    1. Front Matter
      Pages 347-347
    2. Daniel A. Nicholson, Yuri Geinisman
      Pages 349-364
  8. Synaptogenesis and Brain Disorders

    1. Front Matter
      Pages 389-389
    2. Alasdair M. Barr, Clint E. Young, Ken Sawada, William G. Honer
      Pages 391-408
    3. Ridha Joober, Alaa El-Husseini
      Pages 409-418
    4. Barbara Vollmayr, Fritz A. Henn, Mathias Zink
      Pages 419-430
    5. Stephen W. Scheff
      Pages 431-443
    6. Alina J. Webber, Brian R. Christie
      Pages 445-456
    7. Austen J. Milnerwood, Lynn A. Raymond
      Pages 457-471
    8. Karen Brebner, Anthony G. Phillips, Yu Tian Wang, Tak Pan Wong
      Pages 473-484
  9. Back Matter
    Pages 485-497

About this book


Molecular Mechanisms of Synaptogenesis is a compilation of recent exciting findings that summarizes the ever-expanding knowledge of how neuronal contacts develop in the normal brain and how their functions are affected in mental disorders.

In the last decade, advances in molecular and cellular biology, combined with the development of sophisticated fluorescence microscopy tools to visualize synapses in live neurons, have revealed many intriguing and unexpected findings regarding the dynamics of synapse formation. Studies by a number of researchers have identified several critical protein components of synapses and shown the time course of their arrival at the synapse. Several molecules serve to hold the synaptic contacts between nerve cells and regulate their function.

Imbalance in synaptic contact formation and function has been linked to psychiatric disorders such as schizophrenia, autism and mental retardation. The recent advances in basic research, summarized in Molecular Mechanisms of Synaptogenesis, may lay the necessary scientific groundwork to develop treatments targeting synaptogenesis, allowing us to improve the lives of people affected by brain disorders. This book will be an invaluable resource for neurobiologists taking their first steps in the expanding and exciting field of synaptogenesis.


El-Husseini Mechanisms Molecular Synaptogenesis neurons

Editors and affiliations

  • Alexander Dityatev
    • 1
  • Alaa El-Husseini
    • 2
  1. 1.University Medical Center Hamburg-EppendorfHamburgGermany
  2. 2.University of British ColumbiaVancouverCanada

Bibliographic information