Herpesviruses and Immunity

  • Peter G. Medveczky
  • Herman Friedman
  • Mauro Bendinelli

Part of the Infectious Agents and Pathogenesis book series (IAPA)

Table of contents

  1. Front Matter
    Pages i-xx
  2. Patricia L. Ward, Bernard Roizman
    Pages 1-32
  3. Barry T. Ruse, Sally S. Atherton
    Pages 33-51
  4. Edward K. Wagner, David C. Bloom
    Pages 53-77
  5. James P. Stewart, Edward J. Usherwood, Bernadette Dutia, Anthony A. Nash
    Pages 149-163
  6. George Klein
    Pages 165-190
  7. Takeshi Sairenji, Takeshi Kurata
    Pages 191-206
  8. Davida Thorley-Lawson
    Pages 207-229
  9. Hans J. Wolf, Andrew J. Morgan
    Pages 231-246
  10. Hartmut Hengel, Ulrich H. Koszinowski
    Pages 247-264
  11. Jens-Christian Albrecht, Frank Neipel, Bernhard Fleckenstein
    Pages 291-308
  12. Back Matter
    Pages 309-317

About this book


Although virology and immunology are now considered separate disciplines, history shows that these areas ofinvestigation always overlapped and one cannot really exist without the other. This trend has become particularly significant and fruitful in the past few years in the area of herpesvirus research. The genomes of the most important herpesviruses have been sequenced, a significant portion of their genes have been identified, and many secrets of regulation of gene expr- sion have been unraveled. Now this progress sets the stage for a true revolution in herpesvirus research: analysis of interactions between the host and the virus. Because herpesviruses can induce, suppress, and fool the immune system, the most productive herpesvirologists are also expert immunologists, and the current results ofthis interdisciplinary effort are truly remarkable. Because herpesviruses cause many important human diseases, the devel- ment of vaccines against these agents is a very significant goal. This effort is also very challenging because of the complexity of herpesviruses and the lack of sufficient information about immune responses. The remarkable ability of herpesviruses to escape immune responses is - other feature that brings immunology and virology together. Herpesviruses - code many proteins that interact with and down-regulate some key elements of the immune system. Thisproperty of herpesviruses represents amajor challenge in developing strategies against these viruses. On the positive side, these viral proteins also provide novel tools for analyzing specific immune reactions and molecular mechanisms.


immunobiology infection infections protein viral infection virus

Editors and affiliations

  • Peter G. Medveczky
    • 1
  • Herman Friedman
    • 1
  • Mauro Bendinelli
    • 2
  1. 1.University of South Florida College of MedicineTampa
  2. 2.University of PisaPisaItaly

Bibliographic information

  • DOI
  • Copyright Information Kluwer Academic Publishers 2002
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-0-306-45890-3
  • Online ISBN 978-0-306-46808-7
  • Series Print ISSN 1075-1289
  • Buy this book on publisher's site