Targeting Treatment of Soft Tissue Sarcomas

  • Jaap Verweij
  • Herbert M. Pinedo

Part of the Cancer Treatment and Research book series (CTAR, volume 120)

Table of contents

  1. Front Matter
    Pages i-vi
  2. Caroline Seynaeve, Jaap Verweij
    Pages 1-15
  3. Iain Ward, Tara Haycocks, Michael Sharpe, Anthony Griffin, Charles Catton, David Jaffray et al.
    Pages 17-42
  4. Janice N. Cormier, Howard N. Langstein, Peter W. T. Pisters
    Pages 43-63
  5. Dirk J Grünhagen, Flavia Brunstein, Timo L.M. ten Hagen, Albertus N. van Geel, Johannes H.W. de Wilt, Alexander M.M. Eggermont
    Pages 65-79
  6. Judith V.M.G. Bovée, Pancras C.W. Hogendoorn
    Pages 81-97
  7. Jaap Verweij
    Pages 117-127
  8. Jean-Yves Blay, Isabelle Ray-Coquard, Laurent Alberti, Dominique Ranchère
    Pages 151-167
  9. Back Matter
    Pages 181-184

About this book


Recent achievements in the development of new techniques and agents for the treatment of cancer in general as well as for soft tissue sarcomas are tremendous. Molecular biology research has changed the landscape considerably and an increasing number of subtypes of soft tissue sarcomas are related to changes in cellular growth factors in the cell signaling pathways. This enables the development of targeted agents with specific activity against these factors. The presence of the KIT receptor at the surface of the gastrointestinal stroma tumor cell, and the activation constituted by mutations has led to the discovery of an extremely active specific KIT tyrosine kinase inhibitor.

In accordance with the more targeted approach in drug use, the changes in the field of radiation therapy and surgery basically focus on a better targeting of the disease, albeit not yet based on the molecular characteristics. All of these stress the importance of the multidisciplinary approach to the treatment of soft tissue sarcoma that was the focus of previous editions of this book.

Targeting Treatment of Soft Tissue Sarcomas summarizes the recent events in this field, putting the achievements in perspective. Physicians and researchers working in the field of soft tissue sarcomas must be aware of the changes in treatment, the underlying concepts, and of the changes we face in the future.


TNF angiogenesis cell cytogenetics genetics molecular biology pathology radiotherapy surgery targeted therapy tumor

Editors and affiliations

  • Jaap Verweij
    • 1
  • Herbert M. Pinedo
    • 2
  1. 1.Department of Medical OncologyErasmus University Medical CenterRotterdamThe Netherlands
  2. 2.Department of Medical OncologyFree University Medical CenterAmsterdamThe Netherlands

Bibliographic information

  • DOI
  • Copyright Information Kluwer Academic Publishers 2004
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4020-7808-8
  • Online ISBN 978-1-4020-7856-9
  • Series Print ISSN 0927-3042
  • Buy this book on publisher's site