Somatostatin

  • Coimbatore B. Srikant

Part of the Endocrine Updates book series (ENDO, volume 24)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Somatostatin-General Biology

    1. Rania Mouchantaf, Yogesh C. Patel, Ujendra Kumar
      Pages 17-27
    2. Véronique Fabre, Avron D. Spier, Raphaëlle Winsky-Sommerer, José R. Criado, Luis de Lecea
      Pages 29-45
    3. Hervé Tostivint, Michele Trabucchi, Mauro Vallarino, J. Michael Conlon, Isabelle Lihrmann, Hubert Vaudry
      Pages 47-64
    4. Malcolm J. Low, Marcelo Rubinstein, Veronica Otero-Corchon
      Pages 65-80
  3. Expression and Function of Somatostatin Receptors

    1. Jason P. Hannon, Christian Bruns, Gisbert Weckbecker, Daniel Hoyer
      Pages 81-106
    2. Jean Claude Reubi, Beatrice Waser, Jean-Claude Schaer
      Pages 107-121
    3. Robert Gardette, Florence Petit, Stéphane Peineau, Christophe Lanneau, Jacques Epelbaum
      Pages 123-142
    4. Hicham Lahlou, Julie Guillermet, Fabienne Vernejoul, Stéphane Pyronnet, Corinne Bousquet, Louis Buscail et al.
      Pages 159-167
    5. Hans-Jürgen Kreienkamp, Chong Wee Liew, Dietmar Bächner, Marie-Germaine Mameza, Michaela Soltau, Arne Quitsch et al.
      Pages 185-202
  4. Applications in Disease

    1. Dik J. Kwekkeboom, Marion de Jong, Eric P. Krenning
      Pages 203-214
    2. Marion de Jong, Roelf Valkema, Dik J Kwekkeboom, Eric P Krenning
      Pages 233-249
    3. Pekka Häyry, Einari Aavik
      Pages 271-288
    4. Lois E. H. Smith, Maria B. Grant
      Pages 289-295
  5. The Future

About this book

Introduction

Thirty years have passed since somatostatin was discovered and its hormonal function defined [1,2]. The wide range of anatomical distribution and actions of somatostatin and its receptors stimulated intense scientific and clinical interest, and fostered extensive research into all aspects of its biology including regulation of its gene expression, processing of its precursor, biological and cellular actions relating to regulation cell secretion, motility and proliferation. The development of metabolically stable peptide analogs helped define its usefulness in the treatment of endocrine diseases and cancer. The heterogeneity of somatostatin receptors recognized in 1981 [3] was later shown to result from the existence and variable expression of five distinct subtypes that constitutes two distinct subfamilies with distinguishing pharmacological characteristics [4,5]. The molecular cloning of these receptor subtypes reignited the interest in this field leading to a major increase in our insight into the biology of somatostatin and its receptor subtypes, and has led to the design and development of subtype-selective peptide and non-peptide agonists and antagonists. Significant progress has been made in both basic and clinical research on somatostatin. Noteworthy developments include the role of somatostatin in neuronal patterning, delineation of subtype-selective cytostatic / cytotoxic antiproliferative actions, manipulation of cellular signaling by oligomeric association of somatostatin receptor subtypes amongst themselves or with other G protein-coupled receptors, application of radionuclide-tagged derivatives to localize somatostatin receptor positive tumors and their treatment through targeted delivery of radionuclide or chemotoxin tagged agonists through receptor-mediated endocytosis.

Keywords

apoptosis biology cancer cell genetics hormones imaging physiology research tissue

Editors and affiliations

  • Coimbatore B. Srikant
    • 1
  1. 1.Department of MedicineMcGill University Heath CenterMontréalCanada

Bibliographic information

  • DOI https://doi.org/10.1007/b112847
  • Copyright Information Springer Science + Business Media, Inc. 2004
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4020-7799-9
  • Online ISBN 978-1-4020-8033-3
  • Series Print ISSN 1566-0729
  • About this book