Clinical Approach to Infection in the Compromised Host

  • Robert H. Rubin
  • Lowell S. Young
  • Ralph Van Furth

Table of contents

  1. Front Matter
    Pages i-xxv
  2. Robert H. Rubin, Lowell S. Young
    Pages 1-4
  3. Jos W. M. van der Meer, Bart Jan Kullberg
    Pages 5-47
  4. Richard Allen Johnson, Arthur Sober
    Pages 49-110
  5. Robert H. Rubin, Reginald Greene Chest
    Pages 111-162
  6. Allan R. Tunkel, W. Michael Scheld
    Pages 163-214
  7. L. Joseph Wheat, Mitchell Goldman, George A. Sarosi
    Pages 215-247
  8. Lowell S. Young, Robert H. Rubin
    Pages 249-264
  9. Peter Rosenberg M., Jules L. Dienstag
    Pages 335-360
  10. Paul D. Griffiths
    Pages 361-403
  11. Robert T. Schooley, Constance A. Benson
    Pages 421-440
  12. Sarah W. Alexander, Brigitta U. Mueller, Philip A. Pizzo
    Pages 441-464
  13. John C. Christenson, Harry R. Hill
    Pages 465-496
  14. Michael Boeckh, Kieren A. Marr
    Pages 527-571
  15. Robert H. Rubin
    Pages 573-679
  16. Back Matter
    Pages 707-719

About this book


At the beginning of the new millennium, it is opportune to raveling of the molecular pathways of impaired host - review what has been accomplished in the field of infec- fense mechanisms and the characterization of the genetic tious diseases during the last decades of the previous mutations involved, with the prospect of novel strategies century. The paradigm of the immunocompromised host for therapeutic interventions and possible corrective gene has taught much about the pathophysiology of infectious therapy. In this foreword, I will take a helicopter view of diseases, particularly with regard to immunological as- the various aspects of host defense mechanisms with pects of host defense. In the beginning, Robert Good special emphasis on genetic factors, because of their re- called immunodeficiency syndromes “experiments of na- vance for the course and outcome of infections. ture. ” In the 1960s and subsequent decades, the clinical During life, there exist phases of age-related c- and immunological aspects of immune deficiencies were promised immune functions. After birth there is a phys- studied and adequate treatment attempted. A reflection of logical immune deficiency because the production of an- these developments were the three successful meetings on bodies commences slowly upon contact of the neonate these topics in Veldhoven, The Netherlands (1980), Stir- with microorganisms and upon vaccination.


infection infections infectious microorganism pathophysiology physiology

Editors and affiliations

  • Robert H. Rubin
    • 1
    • 2
  • Lowell S. Young
    • 3
  • Ralph Van Furth
  1. 1.Division of Infectious DiseaseBrigham & Women’s HospitalBoston
  2. 2.Center for Experimental Pharmacology and TherapeuticsHarvard University-Massachusetts Institute of Technology Division of Health Sciences and TechnologyCambridge
  3. 3.Kuzell Institute for Arthritis and Infectious Diseases Chief of the Division on Infectious DiseasesPacific California Medical CenterSan Francisco

Bibliographic information