Role of Proteases in the Pathophysiology of Neurodegenerative Diseases

  • Abel Lajtha
  • Naren L. Banik

Table of contents

  1. Front Matter
    Pages ii-xii
  2. M.L. Cuzner
    Pages 5-23
  3. Donald C. Shields, Naren L. Banik
    Pages 25-45
  4. Darrel E. Goll, Valery F. Thompson, Hongqi Li, Jinyang Cong
    Pages 63-73
  5. Dwaine F. Emerich, Raymond T. Bartus
    Pages 75-84
  6. T.R. Shearer, H. Ma, M Shih, K.J. Lampi, C. Fukiage, M. Azuma
    Pages 85-99
  7. Carmela R. Abraham, Franchot Slot
    Pages 101-116
  8. Maria E. Figueiredo-Pereira, Patricia Rockwell
    Pages 137-153
  9. Jörg B. Schulz, Michael A. Moskowitz
    Pages 179-187
  10. Swapan K. Ray, Denise C. Matzelle, Gloria G. Wilford, Lawrence F. Eng, Edward L. Hogan, Naren L. Banik
    Pages 199-226
  11. Vito Turk, Janko Kos, Gregor Guncar, Boris Turk
    Pages 227-240
  12. Peter A. Forsyth, Dylan R. Edwards, Marc A. LaFleur, V. W. Yong
    Pages 241-268
  13. Hahn-Jun Lee, Koichi Suzuki, Takaomi C Saido
    Pages 283-296
  14. Back Matter
    Pages 297-302

About this book


Researchers seeking problems that offer more hope of success often avoid subjects that seem to be difficult to approach experimentally, or subjects for which experimental results are difficult to interpret. The breakdown part of protein turnover in vivo, particularly in nervous tissue, was such a subject in the past – it was difficult to measure and difficult to explore the mechanisms involved. For factors that influence protein metabolism, it was thought that protein content, function, and distribution are controlled only by the synthetic mechanisms that can supply the needed specificity and response to stimuli. The role of breakdown was thought to be only a general metabolic digestion, elimination of excess polypeptides. We now know that the role of breakdown is much more complex: it has multiple functions, it is coupled to turnover, and it can affect protein composition, function, and synthesis. In addition to eliminating abnormal proteins, breakdown has many modulatory functions: it serves to activate and inactivate enzymes, modulate membrane function, alter receptor channel properties, affect transcription and cell cycle, form active peptides, and much more. The hydrolysis of peptide bonds often involves multiple steps, many enzymes, and cycles (such as ubiquination), and often requires the activity of enzyme complexes. Their activation, modification, and inactivation can thus play an important role in biological functions, with numerous families of proteases participating. The specific role of each remains to be elucidated.


Alzheimer Nervous System alzheimer's disease central nervous system cerebral ischemia genes neurodegenerative disorders physiology trauma

Editors and affiliations

  • Abel Lajtha
    • 1
  • Naren L. Banik
    • 2
  1. 1.Nathan S. Kline Institute for Psychiatric ResearchOrangeburg
  2. 2.Medical University of South CarolinaCharleston

Bibliographic information