The Complement System

Novel Roles in Health and Disease

  • Janos Szebeni

Table of contents

  1. Front Matter
    Pages i-xxi
  2. A Piece of Complement History

  3. Pathways, Genetics and Gene Regulation of Complement

    1. Péter Gál, Géza Ambrus, Zsolt Lőrincz, Péter Závodszky
      Pages 19-43
    2. György Ábel, Vincent Agnello
      Pages 45-59
    3. Mate Tolnay, George C. Tsokos
      Pages 61-73
  4. Novel Regulatory Roles of Complement in Health and Disease

    1. Anna Erdei, Eszter Molnár, Eszter Csomor, Zsuzsa Bajtay, József Prechl
      Pages 77-96
    2. Francesco Tedesco, Roberta Bulla, Fabio Fischetti
      Pages 97-127
    3. Claire L. Harris, B. Paul Morgan
      Pages 129-166
    4. Guillermina Girardi, Jane E. Salmon
      Pages 187-199
    5. György Ábel, Vincent Agnello
      Pages 201-228
  5. Exploitation of Complement Proteins in Infection and Cancer

    1. Reinhard Würzner, Peter F. Zipfel
      Pages 231-248
    2. Zoltán Prohászka, Ferenc D. Tóth, Dénes Bánhegyi, George Füst
      Pages 249-264
    3. Michael Kirschfink, Zvi Fishelson
      Pages 265-304
  6. Role of Complement in Autoimmune Diseases, Allergy and Transplantation

    1. George C. Tsokos, Mate Tolnay
      Pages 307-314
    2. Heiko Hawlisch, Marsha Wills-Karp, Christopher L. Karp, Jörg Köhl
      Pages 315-344
    3. Lilian Varga, Henriette Farkas, George Fust
      Pages 345-360
    4. Janos Szebeni
      Pages 361-396
    5. Michael Kirschfink, Tom Eirik Mollnes
      Pages 397-418
  7. Role of Complement in Acute Catastrophic Illnesses

    1. Mary C. Walsh, Melanie L. Hart, Todd Bourcier, Deepak Bhole, Minoru Takahashi, Gregory L. Stahl
      Pages 421-435
    2. Sherry D. Fleming, George C. Tsokos
      Pages 437-449
    3. F. S. Zetoune, P. A. Ward, M. S. Huber-Lang
      Pages 451-464
    4. Markus S. Huber-Lang, J. Vidya Sarma, Firas S. Zetoune, Peter A. Ward
      Pages 465-480
  8. The Complement System as Therapeutical Target

    1. Tom Eirik Mollnes
      Pages 483-516
    2. Richard A. G. Smith, Dirk Esser, Simon H. Ridley, Roberta Bradford
      Pages 531-545
  9. Back Matter
    Pages 547-565

About this book


As a phylogenetically old system complement is now regarded as a part of innate immunity. But it is much more than that. It bridges innate and adapted immunity, participates not only in host defense but also in many essential physiological processes, old and new diseases and adverse conditions. Indeed, complement became a term that almost defies categorization. What was for a long time a subject for a limited number of specialists has now moved into the mainstream of experimental and clinical immunology. In 1973 I visited the Basel Institute of Immunology and met its director, the eminent scientist and Nobel laureate Nils Jerne. When I entered his office he greeted me with the following words: “Complement, does that really exist?” I was never certain whether he wanted only to tease me or whether he sincerely believed that the complement system was an unimportant biological curiosity, a misstep of evolution. But, of course, missteps do not survive the evolutionary process. Little did I foresee the dramatic developments of recent years when Hans J. Müller-Eberhard and I started to unravel the specifics of the action of the cobra venom factor on the complement system in 1968 and defined a new pathway to its activation. An elucidation of the role of the system in diseases and its control for therapeutic reasons is now getting closer to actual realization in the clinic although many problems, in particular those of highly specificinhibition free of side effects, have still to be resolved.


Asthma Sepsis Transplantation antimicrobial autoimmune disease autoimmunity infection infections infectious viral infection

Editors and affiliations

  • Janos Szebeni
    • 1
  1. 1.Walter Reed Army Institute of ResearchSilver Spring

Bibliographic information

  • DOI
  • Copyright Information Springer Science + Business Media, Inc. 2004
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4020-8055-5
  • Online ISBN 978-1-4020-8056-2
  • Buy this book on publisher's site