The ADAM Family of Proteases

  • Nigel M. Hooper
  • Uwe Lendeckel

Part of the Proteases in Biology and Disease book series (PBAD, volume 4)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Judith White, Lance Bridges, Douglas DeSimone, Monika Tomczuk, Tyra Wolfsberg
    Pages 1-28
  3. Keisuke Hoiruchi, Carl P. Blobel
    Pages 29-64
  4. Jörg W. Bartsch, Silvia Naus, Andrea Rittger, Uwe Schlomann, Dirk Wildeboer
    Pages 65-73
  5. Shoichi Ishiura
    Pages 75-83
  6. Paul Saftig, Dieter Hartmann
    Pages 85-121
  7. Ulla M. Wewer, Reidar Albrechtsen, Eva Engvall
    Pages 123-146
  8. Dominique Alfandari
    Pages 147-169
  9. Joaquín Arribas, Soraya Ruiz-Paz
    Pages 171-197
  10. Tiebang Kang, Robert G. Newcomer, Yun-Ge Zhao, Qing-Xiang Amy Sang
    Pages 199-221
  11. Anne M. Fourie
    Pages 223-238
  12. Daniel S. Greenspan, Wei-Man Wang
    Pages 261-282
  13. Carine Le Goff, Suneel S. Apte
    Pages 283-298
  14. Anne-Marie Malfait, Micky Tortorella, Elizabeth Arner
    Pages 299-322
  15. Han-Mou Tsai
    Pages 323-340
  16. Back Matter
    Pages 341-344

About this book


The ADAM Family of Proteases provides the first comprehensive review of the roles of ADAMs and the related ADAMTS proteases in biology and disease. Although a few members of the ADAM (a disintegrin and metalloprotease) family have been known for some time, it is only in recent years through advances in genome sequencing that the large size of this family of zinc metalloproteases has become apparent. These proteins have multiple domains including a protease domain and a disintegrin domain. A branch of the family, called ADAMTS, also have thrombospondin-like motifs. The role of ADAMs and ADAMTS members in a diversity of biological processes is gradually coming to light. For example, some ADAMs have critical roles in the ectodomain shedding of membrane proteins including tumour necrosis factor-a, the cell signalling molecule Notch and the Alzheimer’s amyloid precursor protein. Other ADAM and ADAMTS family members have key roles to play in sperm function and fertility, collagen processing, development, cardiac hypertrophy and arthritis.


biology genome protein proteins sequencing

Editors and affiliations

  • Nigel M. Hooper
    • 1
  • Uwe Lendeckel
    • 2
  1. 1.University of LeedsUK
  2. 2.University of MagdeburgGermany

Bibliographic information