Dipeptidyl Aminopeptidases in Health and Disease

ISBN: 978-0-306-47717-1 (Print) 978-0-306-47920-5 (Online)

Table of contents (42 chapters)

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  1. Front Matter

    Pages i-xxxii

  2. Structure and Function of Dipeptidyl Aminopeptidases

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      Chapter

      Pages 3-17

      Dipeptidyl Peptidase IV Substrates

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      Chapter

      Pages 19-27

      Structure-Function Relationship of DPP IV: Insights into its Dimerisation and Gelatinase Activity

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      Chapter

      Pages 29-35

      Exploration of the Active Site of Dipeptidyl Peptidase IV From Porphyromonas gingivalis

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      Chapter

      Pages 37-47

      Modification of the Biological Activity of Chemokines by Dipeptidyl Peptidase IV — a Side Effect in the Use of Inhibitors?

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      Chapter

      Pages 49-55

      Molecular Chimeras and Mutational Analysis in the Prolyl Oligopeptidase Gene Family

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      Chapter

      Pages 57-63

      The Specificity of DP IV for Natural Substrates is Peptide Structure Determined

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      Chapter

      Pages 65-68

      New Results on the Conformations of Potent DP IV (CD26) Inhibitors bearing the N-terminal MWP Structural Motif

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      Chapter

      Pages 69-72

      Different Inhibition Mechanisms of Dipeptidyl Peptidase IV by Tryptophan Containing Peptides and Amides

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      Chapter

      Pages 73-76

      Re-Uptake Mechanisms of Peptide Fragments after DPP IV-Mediated Proteolysis in the Peripheral Nervous System

  3. DPP IV-Like Enzymes

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      Chapter

      Pages 79-86

      Dipeptidyl Peptidase IV Gene Family

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      Chapter

      Pages 87-94

      Seprase-DPPIV Association and Prolyl Peptidase and Gelatinase Activities of the Protease Complex

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      Chapter

      Pages 95-102

      Dipeptidyl Peptidase-IV Activity and/or Structure Homologues (DASH) in Transformed Neuroectodermal Cells

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      Chapter

      Pages 103-108

      Characterisation of Human DP IV Produced by a Pichia pastoris Expression System

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      Chapter

      Pages 109-113

      Isolation and Characterization of Attractin-2

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      Chapter

      Pages 115-119

      Investigation of DP IV-dependent Protein-Protein Interactions using Surface Plasmon Resonance

  4. Immune Mechanisms and Immune Disorders

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      Chapter

      Pages 123-131

      Synergistic Action of DPIV and APN in the Regulation of T Cell Function

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      Chapter

      Pages 133-143

      CD26/DPP IV in Experimental and Clinical Organ Transplantation

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      Chapter

      Pages 145-153

      CD26 is Involved in the Regulation of T-Cell Plasma Membrane Compartmentation

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      Chapter

      Pages 155-163

      Inhibition of Dipeptidylpeptidase IV (DPP IV, CD26) Activity Modulates Surface Expression of CTLA-4 in Stress-Induced Abortions

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      Chapter

      Pages 165-174

      Dipeptidyl Peptidase IV/CD26 in T Cell Activation, Cytokine Secretion and Immunoglobulin Production

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