Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis Volume 3

  • David Z. D’Argenio
Conference proceedings

Part of the The International Series in Engineering and Computer Science book series (SECS, volume 765)

Table of contents

  1. Front Matter
    Pages i-vii
  2. Mechanism-Based PK/PD

    1. Front Matter
      Pages 1-1
    2. Zexun Zhou, David Z. D’Argenio, Brian L. Robbins, John H. Rodman
      Pages 33-47
    3. Meindert Danhof, Piet H. van der Graaf, Sandra A. G. Visser, Klaas P. Zuideveld
      Pages 49-65
    4. William J. Jusko, Jin Y. Jin, Debra C. Du Bois, Richard R. Almon
      Pages 85-103
    5. Lu Xu, David Z. D’Argenio, Julie L. Eiseman, Merrill J. Egorin
      Pages 105-131
  3. Pharmacometrics

  4. Pharmacotherapy

    1. Front Matter
      Pages 209-209
    2. Gary L. Rosner, Peter Müller, Feng Tang, Timothy Madden, Borje S. Andersson
      Pages 239-253
    3. Robert S. Parker, John M. Harrold, Julie L. Eiseman, William C. Zamboni, Erin Joseph, Sandra Strychor et al.
      Pages 255-274
    4. Kyungsoo Park, David Z. D’Argenio
      Pages 275-293
  5. Back Matter
    Pages 295-318

About these proceedings


Advanced Methods of Pharmacokinetic and Pharmocodynamic Systems Analysis Volume 3 is vital to professionals and academicians working in drug development and bioengineering. Both basic and clinical scientists will benefit from this work.
This book contains chapters by leading researchers in pharmacokinetic/pharmacodynamic modeling and will be of interest to anyone involved with the application of pharmacokinetic and pharmacodynamics to drug development.
The use of mathematical modeling and associated computational methods is central to the study of the absorption, distribution and elimination of therapeutic drugs (pharmacokinetics) and to understanding how drugs produce their effects (pharmacodynamics). From its inception, the field of pharmacokinetics and pharmacodynamics has incorporated methods of mathematical modeling, simulation and computation in an effort to better understand and quantify the processes of uptake, disposition and action of therapeutic drugs. These methods for pharmacokinetic/pharmacodynamic systems analysis impact all aspects of drug development. In vitro, animal and human testing, as well as drug therapy are all influenced by these methods. Modeling methodologies developed for studying pharmacokinetic/ pharmacodynamic processes confront many challenges. This is related in part to the severe restrictions on the number and type of measurements that are available from laboratory experiments and clinical trials, as well as the variability in the experiments and the uncertainty associated with the processes themselves.
The contributions are organized in three main areas: Mechanism-Based PK/PD, Pharmacometrics and Pharmacotherapy. Both professionals and academics will profit from this extensive work.


AIDS Computerassistierte Detektion HIV Radiologieinformationssystem bioengineering

Editors and affiliations

  • David Z. D’Argenio
    • 1
  1. 1.University of Southern CaliforniaLos Angeles

Bibliographic information

  • DOI
  • Copyright Information Kluwer Academic Publishers 2004
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4020-7804-0
  • Online ISBN 978-0-306-48523-7
  • Series Print ISSN 0893-3405
  • Buy this book on publisher's site