From Basic Science to the Bedside

  • Daniel Hollander
  • Guido N. J. Tytgat

Table of contents

  1. Front Matter
    Pages i-xxiv
  2. Introduction

  3. General Approach to Peptic Disease Therapy

  4. Sucralfate: A Nonsystemic Site Protective Agent

    1. Kiyoshige Ochi
      Pages 47-58
    2. W. F. Caspary
      Pages 59-70
  5. Mechanisms of Action of Sucralfate

    1. Gerald P. Morris
      Pages 71-82
    2. Clifford Tasman-Jones
      Pages 83-88
    3. Michael R. Lucey, Tadataka Yamada
      Pages 103-109
    4. Brian A. Hills
      Pages 111-126
    5. Daniel Rachmilewitz
      Pages 127-132
    6. J. A. Louw, G. O. Young, T. A. Winter, I. N. Marks
      Pages 133-140
    7. Hajime Kuwayama
      Pages 141-149
    8. Zsuzsa Sandor, Sandor Szabo
      Pages 151-162
    9. Sandor Szabo, Stefano Kusstatscher, Zsuzsa Sandor, Miki Nagata, Judah Folkman, Y. Shing
      Pages 163-173
    10. Stanislaw J. Konturek, Jan W. Konturek, Tomasz Brzozowski, Bronislaw L. Slomiany, Amelia Slomiany
      Pages 175-189
    11. I. N. Marks, G. O. Young
      Pages 191-196
    12. Susumu Okabe, Yoshiyasu Ogihara, Hiroyuki Koba
      Pages 197-207
    13. Orlando Roy Charles
      Pages 209-214
  6. Safety and Drug Interactions

    1. David R. Mathews, Nicola G. Dahl
      Pages 215-224
    2. Gilles Caillé, Manon Vézina
      Pages 225-238
  7. Sucralfate and Therapy of Peptic Disease

    1. Shiu Kum Lam
      Pages 239-247
    2. Francois Martin
      Pages 249-255
    3. Hans R. Koelz
      Pages 257-270
    4. Orlando Roy Charles
      Pages 271-276
    5. G. Bianchi Porro, F. Santalucia
      Pages 277-288
  8. The Preventive Use of Sucralfate

  9. The Clinical Role of Sucralfate in Peptic Ulcer Therapy—Comparison with H-2 Blockers and Pump Inhibitors: A Projection for the Nineties

  10. Back Matter
    Pages 351-366

About this book


International researchers summarize the current understanding of peptic disease and trace the development of a novel new drug for peptic disease therapy-sucralfate. Contributors present laboratory research along side data from clinical trials as well as from the practice of medicine. Articles discuss the history of sucralfate's development, mechanisms of action, clinical efficacy, and future directions for research. This volume will be of interest to scientists and clinicians working in gastroenterology and gastrointestinal physiology.


chemistry clinical trial drug gastroenterology medicine pathophysiology physiology research

Editors and affiliations

  • Daniel Hollander
    • 1
  • Guido N. J. Tytgat
    • 2
  1. 1.Dean’s OfficeUniversity of Kansas School of MedicineKansas City
  2. 2.Department of Gastroenterology-Hepatology, Academic Medical CenterUniversity of AmsterdamAmsterdamThe Netherlands

Bibliographic information