Bioengineering Approaches to Pulmonary Physiology and Medicine

  • Michael C. K. Khoo

Table of contents

  1. Front Matter
    Pages i-viii
  2. Systems Modeling of Ventilatory Control

  3. Modeling of the Neural Control of Breathing

    1. Chi-Sang Poon
      Pages 93-113
    2. David Paydarfar, Daniel M. Buerkel
      Pages 115-136
  4. Nonlinear Dynamical Analysis of Respiration

    1. Eugene N. Bruce
      Pages 149-159
    2. Bernard Hoop, Melvin D. Burton, Homayoun Kazemi
      Pages 161-173
  5. Modeling of Pulmonary Mechanics and Gas Exchange

    1. R. L. Hughson, Y. Yamamoto, J. -O. Fortrat, R. Leask, M. S. Fofana
      Pages 187-196
  6. Back Matter
    Pages 255-256

About this book


As the current millennium steams towards a close, one cannot help but look with amazement at the incredible amount of progress that has been achieved in medicine in just the last few decades. A key contributing factor to this success has been the importation and blending of ideas and techniques from disciplines outside the traditional borders of medical science. In recent years, the most well-known example is the cross-pollination between molecular biology and medicine. Advances driven by this potent combination have spawned the vision of a future where cures based on gene therapy become commonplace. Yet, as we continue our search for "magic bullets" in the quest to eradicate disease, it important to recognize the value of other less-heralded interdisciplinary efforts that have laid a large part of the foundation of present-day medicine. In pulmonary medicine, the contribution from the bioengineers (a diverse collection of individuals cross-bred to various degrees in mathematical modeling and experimental physiology) has been larger and more sustained than in many other medical specialties. It is easy to point to the vast array of ventilators, blood-gas analyzers, oximeters, pulmonary function devices, and respiration monitors that are present in any modern clinical setting as solid evidence of the successful synergy between engineering science and pulmonary medicine. However, one must not forget the less tangible, but perhaps more important, contributions that have been derived from mathematical modeling and computer simulation, without which many of these modern instruments would not have come into existence.


Monitor bioengineering mathematical modeling mechanics physiology pulmonary mechanics respiration

Authors and affiliations

  • Michael C. K. Khoo
    • 1
  1. 1.University of Southern CaliforniaLos Angeles

Bibliographic information