Apoptosis in Cardiac Biology

  • Heribert Schunkert
  • G. A. J. Riegger

Part of the Basic Science for the Cardiologist book series (BASC, volume 5)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Basic Mechanisms of Apoptosis

    1. Front Matter
      Pages 1-1
    2. The initiation of apoptosis

      1. Jürgen Holtz, Dorothea Darmer
        Pages 5-28
      2. Herbert Schwarz
        Pages 29-37
      3. Rüdiger von Harsdorf
        Pages 39-58
    3. The mediators of apoptosis

      1. Franz Kohlhuber, Dirk Eick
        Pages 61-69
      2. Klaus Schlottmann, Jürgen Schölmerich
        Pages 71-90
      3. Lothar Jahn, Harald Bär
        Pages 101-108
    4. The execution of apoptosis

      1. Thomas Rudel
        Pages 111-121
      2. L. B. Jordan, D. J. Harrison
        Pages 123-135
  3. Cellular Targets in the cardiovascular system

    1. Front Matter
      Pages 137-137
    2. Blood vessels

      1. Ioakim Spyridopoulos
        Pages 141-156
    3. Myocardium

      1. Armin Haunstetter, Markus Haass, Seigo Izumo
        Pages 175-188
      2. Edward G. Lakatta, Xilin Long, Alan Chesley, Michael Crow
        Pages 189-208
  4. Apoptosis in Cardiac Disorders

    1. Front Matter
      Pages 209-209
    2. Vascular disease

      1. Denis deBlois, Sergei Orlov, Pavel Harnet
        Pages 213-222
      2. Gerhard Bauriedel, Randolph Hutter, Ulrich Welsch, Berndt Lüderitz
        Pages 223-236
    3. Cardiac disease

      1. Andreas V. Sigel, Günter A. J. Riegger
        Pages 239-259
      2. Laura Agnoletti, Laura Comini, Giuseppina Gaia, Salvatore Curello, Roberto Ferrari
        Pages 261-271
      3. Hermann Aebert, Joachim P. Schmitt, Heribert Schunkert
        Pages 287-295
  5. Therapeutical Options

    1. Front Matter
      Pages 297-297
    2. Giora Z. Feuerstein
      Pages 299-308
    3. Andreas V. Sigel, Heribert Schunkert
      Pages 309-316
    4. Daniela Grimm, Gilbert Schönfelder, Martin Paul
      Pages 317-327
    5. Christian Grohé, Rainer Meyer, Hans Vetter
      Pages 329-336
    6. Heribert Schunkert
      Pages 337-341
  6. Back Matter
    Pages 343-353

About this book


Apoptosis or programmed cell death is increasingly considered to be a major factor in the development and progression of cardiovascular disease. In patients with heart failure the activation of apoptosis may result in the loss of irreplaceable cardiac myocytes promoting the clinical course of the syndrome. Moreover, in the coronary arteries inflammation and apoptosis may weaken critical structures of the vessel wall leading to plaque rupture and, subsequently, to myocardial infarction. Given these deleterious consequences, it seems almost paradoxical that programmed cell death is an active process that, if initiated under physiological circumstances, is essential for both coordinated tissue growth or destruction of malignant cells.
Apoptosis in Cardiac Biology, written by a team of internationally renowned researchers, gives a timely synopsis of basic mechanisms, cellular and structural targets and, finally, clinical implications of programmed cell death in the heart. The expert authors of this volume give concise overviews on general and cell-specific aspects of programmed cell death in cardiac myocytes and fibroblasts, as well as in vascular smooth muscle and endothelial cells. Furthermore, novel therapeutic options arising from the outstanding pathophysiological significance of cardiac apoptosis are presented.
This comprehensive review of Apoptosis in Cardiac Biology will be of interest to both clinicians and basic researchers who are active in the fields of cardiology and atherosclerosis.


Activation apoptosis atherosclerosis biology cardiovascular cardiovascular system cell cell death heart prevention programmed cell death tissue vascular disease

Editors and affiliations

  • Heribert Schunkert
    • 1
  • G. A. J. Riegger
    • 1
  1. 1.University of RegensburgGermany

Bibliographic information

  • DOI
  • Copyright Information Kluwer Academic Publishers 2000
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-0-7923-8648-3
  • Online ISBN 978-0-585-38143-5
  • Series Print ISSN 1566-0753
  • Buy this book on publisher's site