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Biology of the Arterial Wall

  • Bernard I. Levy
  • Alain Tedgui

Part of the Basic Science for the Cardiologist book series (BASC, volume 1)

Table of contents

  1. Front Matter
    Pages I-XIV
  2. The Vascular Wall under Physiological Conditions

    1. Front Matter
      Pages 1-1
    2. Bernard I. Levy, Alain Tedgui
      Pages 3-12
    3. Bernard I. Levy
      Pages 13-24
    4. Stéphane Laurent
      Pages 25-47
    5. Paul Vanhoutte, Chantal Boulanger
      Pages 49-70
    6. Alain Tedgui, Stéphanie Lehoux, Bernard Levy
      Pages 71-100
    7. Cedric J. Gaultier, Jean-Baptiste Michel
      Pages 101-113
    8. Harry A. J. Struijker Boudier, Frank R. M. Stassen, Ferdinand A. C. le Noble
      Pages 115-128
    9. Joël Belmin
      Pages 129-147
  3. The Vascular Wall under Pathological Conditions

    1. Front Matter
      Pages 149-149
    2. Catherine Bernard
      Pages 151-192
    3. Ziad Mallat, Alain Tedgui
      Pages 193-213
    4. Michel E. Safar
      Pages 215-233
    5. Alain Tedgui, Catherine Bernard, Ziad Mallat
      Pages 235-258
    6. Laurent J. Feldman, Ph. Gabriel Steg
      Pages 259-274
  4. Back Matter
    Pages 275-278

About this book

Introduction

Biology of the Arterial Wall is intended as a general reference text concerned with the biology of the vascular cells and the blood vessel wall under physiological and pathological conditions. One of the major functions of the arteries is to maintain a continuous blood flow to the organs whatever the pressure conditions, thanks to the vasomotor tone of the smooth muscle cells. Great advances have been made over the last decade in the understanding of the endothelial cells as integrators and transducers of signals originating from the blood stream. The pluripotent control functions of the endothelial cells in the vessel wall are now well recognized. A review of endothelial functions and dysfunctions is presented.
Cell biology and molecular genetic studies have now identified an array of molecules elaborated by endothelial cells and vascular smooth muscle cells and by the blood-borne elements which interact with artery cells, defending the artery against injury and modulating evolving abnormal processes. Molecules which induce or inhibit endothelial and/or smooth muscle cells are currently under great scrutiny. Angiogenesis, which plays a major role in tumor growth, but may also be beneficial as a healing process in muscle ischemia, is discussed.
Apoptosis, or programmed cell death, has only recently been recognized as an essential process in blood vessel modeling and remodeling. An overview of apoptosis in the vascular system is presented.
It is increasingly evident that the adjustments of the blood vessel wall are made in the presence of deforming disease processes such as hypertension and atherosclerosis.
The second part of the book is concerned with the blood vessel wall in disease conditions. Several chapters review the role of the vessel and vascular cells in inflammation, and vascular remodeling during arterial hypertension and aging. One chapter is devoted to atherogenesis, atheroma and plaque instability, followed by the pathophysiology of post-angioplasty restenosis, which is a crucial issue in modern interventional cardiology.

Keywords

blood vessel cells endothelium hypertension pathophysiology physiology smooth muscle

Editors and affiliations

  • Bernard I. Levy
    • 1
  • Alain Tedgui
    • 1
  1. 1.Lariboisiére hospitalINSERM U141ParisFrance

Bibliographic information

  • DOI https://doi.org/10.1007/b102335
  • Copyright Information Kluwer Academic Publishers 1999
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-0-7923-8458-8
  • Online ISBN 978-0-585-38146-6
  • Series Print ISSN 1566-0753
  • Buy this book on publisher's site