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Bioinformatics of Non Small Cell Lung Cancer and the Ras Proto-Oncogene

  • Amita Kashyap
  • D. Bujamma
  • Naresh Babu M

Part of the SpringerBriefs in Applied Sciences and Technology book series (BRIEFSAPPLSCIENCES)

Also part of the Forensic and Medical Bioinformatics book sub series (BRIEFSFOMEBI)

Table of contents

  1. Front Matter
    Pages i-vii
  2. Amita Kashyap, M Naresh Babu, D. Bujjamma
    Pages 1-68
  3. Back Matter
    Pages 69-72

About this book

Introduction

Cancer is initiated by activation of oncogenes or inactivation of tumor suppressor genes. Mutations in the K-ras proto-oncogene are responsible for 10–30% of adenocarcinomas. Clinical Findings point to a wide variety of other cancers contributing to lung cancer incidence. Such a scenario makes identification of lung cancer difficult and thus identifying its mechanisms can contribute to the society. Identifying unique conserved patterns common to contributing proto-oncogenes may further be a boon to Pharmacogenomics and pharmacoinformatics. This calls for ab initio/de novo drug discovery that in turn will require a comprehensive in silico approach of Sequence, Domain, Phylogenetic and Structural analysis of the receptors, ligand screening and optimization and detailed Docking studies.

This brief involves extensive role of the RAS subfamily that includes a set of proteins, which cause an over expression of cancer-causing genes like M-ras and initiate tumour formation in lungs. SNP Studies and Structure based drug discovery will also be undertaken.

Keywords

Adenocarcinomas In-silico Drug Designing K-ras Proto-oncogene Ligand Screening Non Small Cell Lung Cancer Pharmacogenomics Pharmacoinformatics Phylogenetic Analysis Ras Proto-Oncogene Tumor Suppressor Genes

Authors and affiliations

  • Amita Kashyap
    • 1
  • D. Bujamma
    • 2
  • Naresh Babu M
    • 3
  1. 1.Biotechnology and BioinformaticsCRRAO AIMSCSHyderabadIndia
  2. 2.Department of BiotechnologyBiotech Consortium India LimitedNew DelhiIndia
  3. 3.Biotechnology and BioinformaticsCRRAO AIMSCSHyderabadIndia

Bibliographic information

  • DOI https://doi.org/10.1007/978-981-4585-08-8
  • Copyright Information The Author(s) 2015
  • Publisher Name Springer, Singapore
  • eBook Packages Engineering
  • Print ISBN 978-981-4585-07-1
  • Online ISBN 978-981-4585-08-8
  • Series Print ISSN 2191-530X
  • Series Online ISSN 2191-5318
  • Buy this book on publisher's site