Detection of Fetal Abnormalities Based on Three Dimensional Nuchal Translucency

  • Khin Wee Lai
  • Eko Supriyanto

Part of the SpringerBriefs in Applied Sciences and Technology book series (BRIEFSAPPLSCIENCES)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Khin Wee Lai, Eko Supriyanto
    Pages 1-9
  3. Khin Wee Lai, Eko Supriyanto
    Pages 95-108
  4. Khin Wee Lai, Eko Supriyanto
    Pages 109-111
  5. Back Matter
    Pages 113-113

About this book


Ultrasound (US) prenatal screening has been proposed as the most effective technique for Trisomy 21 early assessment. Assessment of Nuchal Translucency (NT) offers promising non-invasive method for fetal abnormalities detection up to 75%. Nevertheless, current clinician practice of NT examination by locating the sonogram calipers on 2D US image requires highly trained and competent operators by adhering to a standard tedious protocol; therefore it is prone to errors and hence it decreases the reliability in intra- and inter-observer repeatability.
This Brief provides the basic knowledge regarding Trisomy 21 diseases and its existing detection methods. The restrictions and disadvantages of each method are discussed accordingly. Therefore, a non-invasive early detection method using 3D ultrasound reconstruction of Nuchal Translucency is introduced. This new method for 3D NT assessments has an edge over the previous 2D methods, and entails the composite function in visualizing the explicit internal marker structure. Further, image processing techniques covered from data acquisition, pre-processing, speckle noise reduction and 3D segmentation are also discussed. This should be especially useful for students and professional researchers in the Biomedical and image processing fields.


3D Reconstruction Bland-Altman Test Down Syndrome Fetal Abnormalities Nuchal Translucency Pearson’s Correlation Coefficient Trisomy 21 Ultrasound Prenatal Screening

Authors and affiliations

  • Khin Wee Lai
    • 1
  • Eko Supriyanto
    • 2
  1. 1., Dept. of Clinical Science and EngineerinUniversiti Teknologi MalaysiaSkudai-JohorMalaysia
  2. 2., Clinical Engineering Research LaboratoryUniversiti Teknologi MalaysiaSkudai-JohorMalaysia

Bibliographic information

  • DOI
  • Copyright Information The Author(s) 2013
  • Publisher Name Springer, Singapore
  • eBook Packages Engineering Engineering (R0)
  • Print ISBN 978-981-4021-95-1
  • Online ISBN 978-981-4021-96-8
  • Series Print ISSN 2191-530X
  • Series Online ISSN 2191-5318
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