Peroxisomes: Biogenesis, Function, and Role in Human Disease

  • Tsuneo Imanaka
  • Nobuyuki Shimozawa

Table of contents

  1. Front Matter
    Pages i-xii
  2. Biogenesis and Function of Peroxisome

    1. Front Matter
      Pages 1-1
    2. Tsuneo Imanaka
      Pages 3-13
    3. Kosuke Kawaguchi, Tsuneo Imanaka
      Pages 15-42
    4. Masahide Oku, Yasuyoshi Sakai
      Pages 43-58
    5. Masashi Morita, Tsuneo Imanaka
      Pages 59-104
  3. Dysfunction of Peroxisome and Human Disease

    1. Front Matter
      Pages 105-105
    2. Nobuyuki Shimozawa
      Pages 107-136
    3. Shigeo Takashima, Nobuyuki Shimozawa
      Pages 137-157
    4. Nobuyuki Shimozawa
      Pages 159-169
  4. Topics in Peroxisome Research

    1. Front Matter
      Pages 201-201
    2. Tsuneo Imanaka
      Pages 203-219
    3. Kotaro Hama, Yuko Fujiwara, Kazuaki Yokoyama
      Pages 249-260

About this book


This book provides readers with a comprehensive overview of peroxisomes and their role in human diseases. It starts by describing the history of peroxisome research and then examines in detail the current understanding of the biogenesis and function of peroxisomes. It then focuses on peroxisomal disorders and the involvement of peroxisomes in cancer and age-related diseases, discussing in detail the use of model organisms to elucidate the pathogenesis of peroxisomal disorders and the physiological importance of peroxisomal proteins. Further, the book examines diagnostic and therapeutic strategies in peroxisomal disorders as well as significant recent advances. Lastly, it addresses various topics in peroxisome research, including the isolation of peroxisomes from mammalian tissues and cells, the structural biology of peroxisomal proteins, the lipidomics of peroxisomal disorders, the value of exome sequencing, and neuropsychological testing in X-linked adrenoleukodystrophy. Given its scope, the book is a valuable resource for postgraduate students and researchers in the life sciences and clinicians in the fields of internal medicine, pediatrics, and neurology.


Peroxisome Biogenesis of peroxisome Function of peroxisome Lipid metabolism ABC transporter Solute transporter Peroxisomal disorders PEX gene X-linked adrenoleukodystophy Very long chain fatty acid

Editors and affiliations

  • Tsuneo Imanaka
    • 1
  • Nobuyuki Shimozawa
    • 2
  1. 1.Faculty of Pharmaceutical Sciences, Hiroshima International University, Kure, Hiroshima, JapanUniversity of ToyamaToyamaJapan
  2. 2.Division of Genomics Research, Life Science Research Center, Gifu University, Gifu, JapanDepartment of Pediatrics, Gifu University School of MedicineGifuJapan

Bibliographic information