Renal Fibrosis: Mechanisms and Therapies

  • Bi-Cheng Liu
  • Hui-Yao Lan
  • Lin-Li Lv

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1165)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Renal Fibrosis in Chronic Kidney Disease

    1. Front Matter
      Pages 1-1
    2. Ji-Cheng Lv, Lu-Xia Zhang
      Pages 3-15
    3. Ping-Sheng Chen, Yi-Ping Li, Hai-Feng Ni
      Pages 17-36
    4. Cheng Xue, Chang-Lin Mei
      Pages 81-100
    5. Cheng Yang, Ruochen Qi, Bin Yang
      Pages 101-116
  3. Resident and infiltrating cell activation in renal fibrosis

    1. Front Matter
      Pages 143-143
    2. Zhen Yang, Li-Jie He, Shi-Ren Sun
      Pages 145-163
    3. Jing-Hong Zhao
      Pages 165-194
    4. Chen-Chen Lu, Gui-Hua Wang, Jian Lu, Pei-Pei Chen, Yang Zhang, Ze-Bo Hu et al.
      Pages 195-232
    5. Bi-Cheng Liu, Tao-Tao Tang, Lin-Li Lv
      Pages 233-252
    6. Qian Yuan, Roderick J. Tan, Youhua Liu
      Pages 253-283
    7. Xiao-Ming Meng, Thomas Shiu-Kwong Mak, Hui-Yao Lan
      Pages 285-303
    8. Changlong An, Li Jia, Jia Wen, Yanlin Wang
      Pages 305-322
  4. Mediators and Cellular Processes in Renal Fibrosis

    1. Front Matter
      Pages 323-323
    2. Aanchal Shrestha, Ruo-Chen Che, Ai-Hua Zhang
      Pages 325-346
    3. Tao-Tao Ma, Xiao-Ming Meng
      Pages 347-364
    4. Qing Yin, Hong Liu
      Pages 365-380
    5. Xiao-Ming Meng
      Pages 381-406
    6. Liang Li, Wei Tang, Fan Yi
      Pages 407-421
    7. Yi Wen, Steven D. Crowley
      Pages 443-454
    8. Zuo-Lin Li, Bi-Cheng Liu
      Pages 467-485
    9. Mohammed Mazheruddin Quadri, Syeda-Safoorah Fatima, Ruo-Chen Che, Ai-Hua Zhang
      Pages 501-524
    10. Xiao-Gang Du, Xiong-Zhong Ruan
      Pages 525-541
    11. Xing-Chen Zhao, Man J. Livingston, Xin-Ling Liang, Zheng Dong
      Pages 557-584
    12. Hua Su, Cheng Wan, Anni Song, Yang Qiu, Wei Xiong, Chun Zhang
      Pages 585-604
  5. Biomarkers and Treatment of Renal Fibrosis

    1. Front Matter
      Pages 605-605
    2. Le-Ting Zhou, Lin-Li Lv, Bi-Cheng Liu
      Pages 607-623
    3. Feng Liu, Shougang Zhuang
      Pages 625-659
    4. Jian-Si Li, Bing Li
      Pages 661-670
    5. Ying-Ying Zhang, Ying Yu, Chen Yu
      Pages 671-691

About this book


This book systemically presents the latest research on renal fibrosis, covering all the major topics in the field, including the possible mechanisms, biomarkers, and strategies for prevention and treatment of chronic kidney disease (CKD). Due to its high prevalence, CKD represents a huge global economic and social burden. Irrespective of the initial causes, CKD progresses to end stage kidney disease (ESKD) due to renal fibrosis, which is characterized by glomerulosclerosis, tubule atrophy and atresia, and the excessive accumulation of extracellular matrix (ECM) in the kidney. Unfortunately, an estimated 1%-2% of the adult population living with CKD will need renal replacement therapy at some point as a result of ESKD. As such, strategies for preventing or slowing CKD progression to ESKD are of utmost importance, and studies aiming to understand the mechanisms of renal fibrosis have been the focus of intensive research. Recently, novel insights into the pathophysiological processes have furthered our understanding of the pathogenesis of renal fibrosis, and more importantly, promoted studies on the early diagnosis and treatment of CKD. This book draws lessons from the extensive, state-of-the-art research in this field, elaborating the new theories and new techniques to offer readers a detailed and comprehensive understanding of renal fibrosis and as well as inspiration for future research directions.


Renal diseases Fibrosis Pathogenesis Biomarker Therapy

Editors and affiliations

  • Bi-Cheng Liu
    • 1
  • Hui-Yao Lan
    • 2
  • Lin-Li Lv
    • 3
  1. 1.Zhongda Hospital, Southeast University School of MedicineSoutheast UniversityNanjingChina
  2. 2.Department of Medicine and Therapeutics, Li Ka Shing Institute of Health SciencesChinese University of Hong KongHong KongHong Kong
  3. 3.Zhongda Hospital, Southeast University School of MedicineSoutheast UniversityNanjingChina

Bibliographic information