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Protein Allostery in Drug Discovery

  • Jian Zhang
  • Ruth Nussinov
Book

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1163)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Xi Cheng, Hualiang Jiang
    Pages 1-23
  3. Ruth Nussinov, Chung-Jung Tsai, Hyunbum Jang
    Pages 25-43
  4. Takayoshi Kinoshita
    Pages 45-64
  5. Kun Song, Jian Zhang, Shaoyong Lu
    Pages 65-87
  6. Weilin Zhang, Juan Xie, Luhua Lai
    Pages 89-105
  7. Xinheng He, Duan Ni, Shaoyong Lu, Jian Zhang
    Pages 107-139
  8. Hazem Abdelkarim, Ben Hitchinson, Avik Banerjee, Vadim Gaponenko
    Pages 171-186
  9. Yiran Wu, Jiahui Tong, Kang Ding, Qingtong Zhou, Suwen Zhao
    Pages 225-251
  10. Resmi C. Panicker, Souvik Chattopadhaya, Anthony G. Coyne, Rajavel Srinivasan
    Pages 253-278
  11. Alejandro E. Leroux, Lissy Z. F. Gross, Mariana Sacerdoti, Ricardo M. Biondi
    Pages 279-311
  12. Duan Ni, Na Liu, Chunquan Sheng
    Pages 313-334
  13. Ashfaq Ur Rehman, Mueed Ur Rahman, Taaha Arshad, Hai-Feng Chen
    Pages 335-357
  14. Scott D. Gorman, Rebecca N. D’Amico, Dennis S. Winston, David D. Boehr
    Pages 359-384

About this book

Introduction

The book focuses on protein allostery in drug discovery. Allosteric regulation, ʹthe second secret of lifeʹ, fine-tunes virtually most biological processes and controls physiological activities. Allostery can both cause human diseases and contribute to development of new therapeutics. Allosteric drugs exhibit unparalleled advantages compared to conventional orthosteric drugs, rendering the development of allosteric modulators as an appealing strategy to improve selectivity and pharmacodynamic properties in drug leads. The Series delineates the immense significance of protein allostery—as demonstrated by recent advances in the repertoires of the concept, its mechanistic mechanisms, and networks, characteristics of allosteric proteins, modulators, and sites, development of computational and experimental methods to predict allosteric sites, small-molecule allosteric modulators of protein kinases and G-protein coupled receptors, engineering allostery, and the underlying role of allostery in precise medicine. Comprehensive understanding of protein allostery is expected to guide the rational design of allosteric drugs for the treatment of human diseases. The book would be useful for scientists and students in the field of protein science and Pharmacology etc. 

Keywords

Allosteric Drug Discovery Allosteric Modulator Allosteric Regulation Allosteric Site Protein Allostery

Editors and affiliations

  • Jian Zhang
    • 1
  • Ruth Nussinov
    • 2
  1. 1.Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of EducationShanghai Jiao Tong University, School of MedicineShanghaiChina
  2. 2.Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD, USASackler Institute of Molecular Medicine, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv UniversityTel AvivIsrael

Bibliographic information

  • DOI https://doi.org/10.1007/978-981-13-8719-7
  • Copyright Information Springer Nature Singapore Pte Ltd. 2019
  • Publisher Name Springer, Singapore
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-981-13-8718-0
  • Online ISBN 978-981-13-8719-7
  • Series Print ISSN 0065-2598
  • Series Online ISSN 2214-8019
  • Buy this book on publisher's site