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Actin Polymerization in Apicomplexan

A Structural, Functional and Evolutionary Analysis

  • Avinash Kale
Book

Table of contents

  1. Front Matter
    Pages i-xi
  2. Samridhi Pathak, Sarita Tripathi, Ricka Gauba, Sarath Chandra Dantu, Avinash Kale
    Pages 1-14
  3. Samridhi Pathak, Ricka Gauba, Sarath Chandra Dantu, Avinash Kale
    Pages 15-28
  4. Samridhi Pathak, Ricka Gauba, Sarath Chandra Dantu, Dhriti Sheth, Avinash Kale
    Pages 29-38
  5. Samridhi Pathak, Ricka Gauba, Sarath Chandra Dantu, Avinash Kale
    Pages 39-50
  6. Samridhi Pathak, Ricka Gauba, Sarath Chandra Dantu, Avinash Kale
    Pages 51-62
  7. Samridhi Pathak, Ricka Gauba, Sarath Chandra Dantu, Avinash Kale
    Pages 63-68
  8. Samridhi Pathak, Ricka Gauba, Sarath Chandra Dantu, Avinash Kale
    Pages 69-75
  9. Samridhi Pathak, Ricka Gauba, Sarath Chandra Dantu, Avinash Kale
    Pages 77-83
  10. Samridhi Pathak, Ricka Gauba, Sarath Chandra Dantu, Avinash Kale
    Pages 85-91
  11. Samridhi Pathak, Ricka Gauba, Avinash Kale
    Pages 93-97
  12. Back Matter
    Pages 99-101

About this book

Introduction

This book discusses in detail the structural, evolutionary and functional role of actin and its regulatory proteins in gliding motility in apicomplexan organisms, a unique phenomenon found in actin-myosin cytoskeletal elements.

The book also explores the potential of different actin regulators, namely formin, profilin, actin depolymerization factor (ADF), capping proteins (CPα and CPβ), cyclase-associated protein (CAP) and coronin 13–24 as potential drug targets against malaria.  As the chief components of the gliding motor, the actin-regulator proteins are characterized by unique features that make them promising targets for structure-based drug design.

Lastly, the book proposes a mathematical model, based on kinetic data mining, to help understand the most vital regulators for actin polymerization dynamics.

Keywords

Apicomplexans Actin regulation Gliding motility Mathematical model Evolution

Editors and affiliations

  • Avinash Kale
    • 1
  1. 1.School of Chemical SciencesUM-DAE Centre for Excellence in Basic Sciences (CEBS)MumbaiIndia

Bibliographic information