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© 2019

Medical Applications of iPS Cells

Innovation in Medical Sciences

  • Haruhisa Inoue
  • Yukio Nakamura
Book

Part of the Current Human Cell Research and Applications book series (CHCRA)

Table of contents

  1. Front Matter
    Pages i-x
    PDF

  2. Introduction

    1. Front Matter
      Pages 1-1
      PDF
    2. Clinical Potential of Induced Pluripotent Stem Cells
      Peter Karagiannis
      Pages 3-12

  3. Disease Modelling

    1. Front Matter
      Pages 13-13
      PDF
    2. Disease Modeling of Hematological and Immunological Disorders Using Induced Pluripotent Stem Cells
      Megumu K. Saito
      Pages 15-27
    3. iPS Cell Technology for Dissecting Cancer Epigenetics
      Hirofumi Shibata, Yasuhiro Yamada
      Pages 29-43
    4. Recapitulating Hematopoietic Development in a Dish
      Kim Vanuytsel, Martin H. Steinberg, George J. Murphy
      Pages 45-71
    5. Modeling Cardiomyopathies with iPSCs
      Jean-Sébastien Hulot
      Pages 73-95

  4. Molecular Technologies

    1. Front Matter
      Pages 97-97
      PDF
    2. Endogenous Signal-Responsive Transgene Switch Systems for Visualization and Purification of Specific Cells
      Hideyuki Nakanishi, Hirohide Saito
      Pages 99-112
    3. Precision Genome Editing in Human-Induced Pluripotent Stem Cells
      Knut Woltjen
      Pages 113-130

  5. iPS Applications

    1. Front Matter
      Pages 131-131
      PDF
    2. Induced Pluripotent Stem Cell-Based Cell Therapy of the Retina
      Seiji Takagi, Michiko Mandai, Yasuhiko Hirami, Yasuo Kurimoto, Masayo Takahashi
      Pages 133-147
    3. Organoid Models of Development and Disease Towards Therapy
      Yasunori Nio, Takanori Takebe
      Pages 149-168
    4. In Vivo Cell Conversion as a New Cell Therapy
      Hedong Li, Lei Zhang, Yuchen Chen, Zheng Wu, Zhuofan Lei, Gong Chen
      Pages 169-190

About this book

Introduction

This volume highlights recent advances using iPS cells in disease modeling and medical applications along with new technologies that enhance the power of iPS cells. While the discovery of iPS cells has provided excellent opportunities for developing models of human diseases, platforms for drug discovery and cell therapies, iPS cell technology still faces many challenges. Presenting the latest advances in this rapidly evolving research area, this book is intended to widen the community of researchers and clinicians interested in the exciting field of iPS cells.

Keywords

Disease modelling iPSC application Reprogramming cancer cells Stem cells Genome editing Cell replacement therapy

Editors and affiliations

  • Haruhisa Inoue
    • 1
  • Yukio Nakamura
    • 2
  1. 1.CiRA, Kyoto UniversityKyotoJapan
  2. 2.Cell Engineering DivisionRIKEN BioResource Research CenterTsukuba-shi IbarakiJapan

About the editors

Haruhisa Inoue, CiRA, Kyoto University, Japan; RIKEN BRC, Japan; RIKEN AIP, JAPAN
Yukio Nakamura, RIKEN BioResource Center, Japan

Bibliographic information

  • Book Title Medical Applications of iPS Cells
  • Book Subtitle Innovation in Medical Sciences
  • Editors Haruhisa Inoue
    Yukio Nakamura
  • Series Title Current Human Cell Research and Applications
  • Series Abbreviated Title Current Human Cell Research and Applications
  • DOI https://doi.org/10.1007/978-981-13-3672-0
  • Copyright Information Springer Nature Singapore Pte Ltd. 2019
  • Publisher Name Springer, Singapore
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-981-13-3671-3
  • eBook ISBN 978-981-13-3672-0
  • Series ISSN 2522-073X
  • Series E-ISSN 2522-0748
  • Edition Number 1
  • Number of Pages X, 190
  • Number of Illustrations 0 b/w illustrations, 24 illustrations in colour
  • Topics Oncology
    Cell Biology
  • Buy this book on publisher's site

Reviews

“The book is most appropriate for those with a basic understanding of molecular biology and stem cell function, with value for students, researchers, and instructors interested in the area of iPS cell biology. … it serves as an excellent resource for those studying this topic and provides a chronological perspective, appropriately discussing many of the key applications and challenges.” (Thomas Bodenstine, Doody's Book Reviews, June 21, 2019)