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Human Pathobiochemistry

From Clinical Studies to Molecular Mechanisms

  • Toshitaka Oohashi
  • Hirokazu Tsukahara
  • Francesco Ramirez
  • Chad L. Barber
  • Fumio Otsuka
Textbook

Table of contents

  1. Front Matter
    Pages i-xi
  2. Metabolic Disorders

    1. Front Matter
      Pages 1-1
    2. Yuan-Zong Song, Masahide Yazaki, Takeyori Saheki
      Pages 3-14
    3. Ken Sakurai, Toya Ohashi
      Pages 33-41
    4. Masa-aki Kawashiri, Daniel J. Rader
      Pages 43-56
    5. Hiroyuki Ida
      Pages 57-65
    6. Akihiro Yachie
      Pages 67-79
    7. John H. Walter, Henk J. Blom
      Pages 81-90
    8. Takeshi Taketani, Chigusa Oyama, Yasuaki Oda, Lynne Murphy
      Pages 91-100
    9. Ikue Hata, Miori Yuasa, Yuko Isozaki
      Pages 101-110
    10. Ken-ichi Hirano, Ming Li, Yoshihiko Ikeda
      Pages 111-119
    11. Kimitoshi Nakamura, Jun Kido, Shirou Matsumoto
      Pages 121-132
    12. Norikazu Shimizu, Tsugutoshi Aoki
      Pages 133-141
  3. Genetics

    1. Front Matter
      Pages 143-143
    2. Kosei Hasegawa, Hiroyuki Tanaka, Yoshiki Seino
      Pages 145-154
    3. Amy L. Cummings, Darren Pan, Gary J. Schiller
      Pages 155-168
    4. Nobuaki Miyahara, Kuniaki Seyama, Erwin W. Gelfand
      Pages 169-177
    5. Masataka Ishimura, Shouichi Ohga
      Pages 179-188
    6. Noriaki Shoji, Ernst J. Reichenberger, Yasuyoshi Ueki
      Pages 189-200
    7. Shinya Toyokuni
      Pages 201-207
    8. Motoi Kanagawa, Hideki Tokuoka, Tatsushi Toda
      Pages 209-221
    9. Hiroyasu Tsukaguchi
      Pages 223-239
    10. Francesco Ramirez, Julie De Backer
      Pages 241-254
  4. Others

    1. Front Matter
      Pages 267-267
    2. Daisuke Katagiri, Eisei Noiri, Ryo Matsuura, Raymond C. Harris
      Pages 269-277
    3. Katsuhiro Kobayashi, Tomoyuki Akiyama, Cristina Go
      Pages 295-310
    4. Kyung-Nam Koh
      Pages 311-322
    5. Etsuko Iio, Yasuhito Tanaka
      Pages 323-330
    6. Hiromichi Naito, Tetsuya Yumoto, Clifton W Callaway
      Pages 331-343
  5. Back Matter
    Pages 345-349

About this book

Introduction

This textbook uses a case-study approach to present the core principles of biochemistry and molecular biology in the context of human disease to students who will be involved in patient care. The 29 clinical cases have been carefully selected to cover key scientific concepts and some common, and other not so common, diseases. While the principal focus is on topics relating to metabolic disease, further subjects such as connective tissue disorders, neurological disorders, auto-inflammatory disorders, infective diseases, and cancer are also addressed. Each chapter provides a specific patient report that includes the natural history, pertinent clinical laboratory data, physical findings, subsequent diagnosis, and therapy. This is followed by a comprehensive discussion of the normal biochemical processes and reactions pertaining to the case, along with the pathophysiological mechanisms of the disease. Graphical diagrams are provided in each chapter for ease of comprehension.


Keywords

Molecular mechanisms of disease Metabolic Disorders Genetic Disorders Immunology Cancer

Editors and affiliations

  • Toshitaka Oohashi
    • 1
  • Hirokazu Tsukahara
    • 2
  • Francesco Ramirez
    • 3
  • Chad L. Barber
    • 4
  • Fumio Otsuka
    • 5
  1. 1.Department of Molecular Biology and Biochemistry, Graduate School of Medicine, Dentistry and Pharmaceutical SciencesOkayama UniversityOkayamaJapan
  2. 2.Department of Pediatrics, Graduate School of Medicine, Dentistry and Pharmaceutical SciencesOkayama UniversityOkayamaJapan
  3. 3.Department of Pharmacological SciencesIcahn School of Medicine at Mount SinaiNew YorkUSA
  4. 4.Department of Biology College of Arts and SciencesCalifornia Lutheran UniversityThousand OaksUSA
  5. 5.Department of General Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical SciencesOkayama UniversityOkayamaJapan

Bibliographic information