Perinatal Stem Cells

Biology, Manufacturing and Translational Medicine

  • Zhong Chao Han
  • Tsuneo A. Takahashi
  • Zhibo Han
  • Zongjin Li

Table of contents

  1. Front Matter
    Pages i-vi
  2. Zongjin Li, Zhong Chao Han
    Pages 1-7
  3. Mirja Krause, Jonathan Lozano, Rebecca Lim
    Pages 9-26
  4. Yan Zhang, Zongjin Li, Na Liu
    Pages 27-37
  5. Paolo Rebulla, Sergi Querol, Alejandro Madrigal
    Pages 75-82
  6. S. Ferratge, J. Boyer, N. Arouch, F. Chevalier, G. Uzan
    Pages 111-119

About this book


This book provides a comprehensive introduction to various types of perinatal stem cells. Given their unique regenerative abilities, stem cells offer a promising avenue in the treatment of degenerative diseases or injury.

Currently, the limitations of postnatal cell sources and expanding efficiency may limit autologous stem cell therapies. Although embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) can be cultured indefinitely ex vivo, and can differentiate into three germ layers, ethical issues, the teratoma formation of ESCs and oncogenic risk of iPSCs are major obstacles to their clinical application. More recently, perinatal stem cells have been isolated from the umbilical cord, Wharton’s Jelly, placenta, amniotic membrane and amniotic fluid, which are normally discarded as medical waste. This book, after describing perinatal stem cells in detail, introduces readers to the various types of perinatal stem cells, addressing their characterization, banking, quality control and stability. Importantly, it also reviews the clinical applications of perinatal stem cells to therapy of diseases. Accordingly, it offers a valuable resource for clinicians, researchers and graduate students alike.


Perinatal stem cells Hematopoietic stem cells Mesenchymal stem cells Stem cell therapy Regeneration medicine

Editors and affiliations

  • Zhong Chao Han
    • 1
  • Tsuneo A. Takahashi
    • 2
  • Zhibo Han
    • 3
  • Zongjin Li
    • 4
  1. 1.Beijing Engineering Laboratory of Perinatal Stem CellsJiangxi Engineering Research Center for Stem Cell, Health & Biotech Co.BeijingChina
  2. 2.Institute for Frontier Medical SciencesKyoto UniversityKyotoJapan
  3. 3.State Key Lab of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical SciencesTianjinChina
  4. 4.School of MedicineNankai UniversityTianjinChina

Bibliographic information

  • DOI
  • Copyright Information Springer Nature Singapore Pte Ltd. 2019
  • Publisher Name Springer, Singapore
  • eBook Packages Medicine
  • Print ISBN 978-981-13-2702-5
  • Online ISBN 978-981-13-2703-2
  • Buy this book on publisher's site