Minorities and Small Numbers from Molecules to Organisms in Biology

Toward a New Understanding of Biological Phenomena

  • Takeharu Nagai
  • Yuichi Togashi

Table of contents

  1. Front Matter
    Pages i-xii
  2. Hiroyuki Noji
    Pages 45-51
  3. Hajime Fukuoka, Yong-Suk Che, Akihiko Ishijima
    Pages 115-125
  4. Back Matter
    Pages 145-150

About this book


This book provides an accessible introduction to an exciting new field of life science in which the focus is on small numbers of molecules and minorities within cell populations and their significance for the understanding of biological phenomena. Numbers, or quantitative data, are attracting more attention in cell biology following, for example, determination of the absolute copy number of each protein species in each bacterial cell and the recognition of leader cells that drive collective cell migration. Within this context, the authors present recent advances in experimental techniques, biological findings, and theories. A variety of cutting-edge topics and issues are addressed, with explanation of the ways in which recent developments in the field cast light on seemingly straightforward but difficult-to-answer questions. Readers will learn that we are on the verge of a paradigm shift as the importance of cooperation among groups of molecules in live cells is acknowledged. The book is designed to be enjoyable to read and easy to understand. It will be of interest for a wide range of readers, including young researchers and undergraduate/high school students.


Low Copy Number Single Molecule Measurement Digital Biology Cooperativity Coherency Discetenes

Editors and affiliations

  • Takeharu Nagai
    • 1
  • Yuichi Togashi
    • 2
  1. 1.The Institute of Scientific and Industrial ResearchOsaka UniversityIbarakiJapan
  2. 2.Department of Mathematical and Life Sciences, Graduate School of ScienceHiroshima UniversityHigashi-HiroshimaJapan

Bibliographic information