© 2018

Systematic Exploration of Indolizine-Based Small Fluorescent Molecules

Synthesis, Analysis and Application


Part of the Springer Theses book series (Springer Theses)

Table of contents

About this book


This thesis describes an in-depth study of an indolizine-based fluorophore, from understanding of its structure-photophysical property relationship to its application as a useful biological reporter.

Organic fluorophores have been extensively used in the field of molecular biology owing to their excellent photophysical property, suitable cell permeability, and synthetic flexibility. Understanding of the structure-photophysical property relationship of a given fluorophore often paves the road to the development of valuable molecular probes to visualize and transcribe biological networks. In this thesis, respective chapters deal with molecular design, organic synthesis, structure-property analysis, and quantum-mechanical interpretation of unexplored family of indolizine-based molecules. This systematic exploration has led to rational development of a new microalgae lipid droplet probe, colorful bioorthogonal fluorogenic probes, and a bright mitochondrial probe, working under live cell conditions.

Harnessing the optical properties of a given fluorophore has been an important topic for a couple of decades, both in industry and in academia. This thesis provides useful insights for the improvement and development of unique small fluorescent materials, or optical materials.


Molecular Fluorescence Organic Fluorophores Photophysical Parameters Indolizine-Based Seoul-Fluor System SF-Based Lipid Droplet Bioprobes Molecular Lipophilicity Tetrazine-Containing Colorful Bioorthogonal Probes Indolizine Core Skeleton Furoindolizine Core Skeleton

Authors and affiliations

  1. 1.Department of Chemistry, College of Natural SciencesSeoul National UniversitySeoulKorea (Republic of)

About the authors

Dr. Youngjun Lee is a member of CRI Center for Chemical Proteomics, Department of Chemistry, Seoul National University, Korea. He earned Ph.D. degree in organic chemistry at SNU in February 2018.

Bibliographic information