Targeting Protein-Protein Interactions by Small Molecules

  • Chunquan Sheng
  • Gunda I. Georg

Table of contents

  1. Front Matter
    Pages i-xi
  2. Current Strategies for the Discovery of Small-Molecule Inhibitors of Protein-Protein Interactions

  3. Case Studies of Small-Molecule Inhibitors of Protein-Protein Interactions

    1. Front Matter
      Pages 177-177
    2. Liyan Yue, Wei Wan, Pan Xu, Linjuan Li, Chen Wang, Yuanyuan Zhang et al.
      Pages 179-211
    3. Zhenyuan Miao, Xianghong Guan, Jiewei Jiang, Gunda I. Georg
      Pages 287-315
    4. Jiahui Liu, Ning Kang, Yaxue Zhao, Mingyan Zhu
      Pages 317-329

About this book


This book comprehensively reviews the state-of-the-art strategies developed for protein-protein interaction (PPI) inhibitors, and highlights the success stories in new drug discovery and development. Consisting of two parts with twelve chapters, it demonstrates the design strategies and case studies of small molecule PPI inhibitors. The first part discusses various discovery strategies for small molecule PPI inhibitors, such as high throughput screening, hot spot-based design, computational approaches, and fragment-based design. The second part presents recent advances in small molecule inhibitors, focusing on clinical candidates and new PPI targets. This book has broad appeal and is of significant interest to the pharmaceutical science and medicinal chemistry communities.  



Protein-protein interactions Small molecule inhibitors Hot spots High throughput screening Fragment based drug discovery Secondary structure mimetics p53-MDM2 β Catenin/T-Cell Factor Keap1-Nrf2

Editors and affiliations

  • Chunquan Sheng
    • 1
  • Gunda I. Georg
    • 2
  1. 1.School of PharmacySecond Military Medical UniversityShanghaiChina
  2. 2.College of PharmacyUniversity of MinnesotaMinneapolisUSA

Bibliographic information