Treatment Strategy for Unexplained Infertility and Recurrent Miscarriage

  • Keiji Kuroda
  • Jan J. Brosens
  • Siobhan Quenby
  • Satoru Takeda

Table of contents

  1. Front Matter
    Pages i-viii
  2. Unexplained Infertility

    1. Front Matter
      Pages 1-1
    2. Keiji Kuroda
      Pages 3-5
    3. Takashi Yamaguchi, Keiji Kuroda, Atsushi Tanaka, Seiji Watanabe
      Pages 7-17
    4. Yuko Ikemoto, Keiji Kuroda, Yasushi Kuribayashi, Masato Inoue
      Pages 19-31
  3. Unexplained Recurrent Miscarriage

    1. Front Matter
      Pages 77-77
    2. Keiji Kuroda
      Pages 95-104
    3. Keisuke Murakami, Keiji Kuroda, Jan J. Brosens
      Pages 105-114

About this book


This book offers a highly informative guide to treating unexplained infertility and recurrent miscarriage (RM). In particular, it provides detailed treatment strategies for infertility or RM derived from uterine circumstance such as chronic endometritis and perturbation of endometrial decidualization, as well as maternal immunological rejection of an embryo as semi-allograft.

Unexplained infertility refers to those types that cannot be detected by the general screening test. The causes are sometimes detected in the course of treatment with assisted reproductive technology including IVF. However, some unexplained infertility is intractable even after intracytoplasmic sperm injection or repeated implantation of morphologically suitable embryos. Patients with unexplained RM also have a high likelihood of undetectable risk factors of miscarriage. As a result, gynecologists often repeatedly provide these couples with general treatments for infertility and miscarriage or even discontinue treatment because they cannot detect the reason, which places serious financial, physical and mental burdens on the couples affected.

This book offers gynecologists essential insights into the pathological condition of unexplained infertility and RM, equipping them to identify it, explain it to patients, and consider further examinations and more aggressive fertility treatments.


Unexplained infertility Recurrent miscarriage Chronic endometritis The round spermatid injection (ROSI) TH1/Th2 cells 25 OH-vitamin D NK cell activity

Editors and affiliations

  • Keiji Kuroda
    • 1
  • Jan J. Brosens
    • 2
  • Siobhan Quenby
    • 3
  • Satoru Takeda
    • 4
  1. 1.Center for Reproductive Medicine and Implantation ResearchSugiyama Clinic ShinjukuTokyoJapan
  2. 2.Department of Obstetrics and GynaecologyFaculty of Medicine, Juntendo UniversityTokyoJapan
  3. 3.The Division of Biomedical SciencesClinical Science Research Laboratories Warwick Medical SchoolCoventryUnited Kingdom
  4. 4.Department of Obstetrics and GynaecologyJuntendo UniversityTokyoJapan

Bibliographic information

  • DOI
  • Copyright Information Springer Nature Singapore Pte Ltd. 2018
  • Publisher Name Springer, Singapore
  • eBook Packages Medicine
  • Print ISBN 978-981-10-8689-2
  • Online ISBN 978-981-10-8690-8
  • Buy this book on publisher's site