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Protein-Protein and Domain-Domain Interactions

  • Pandjassarame Kangueane
  • Christina Nilofer

Table of contents

  1. Front Matter
    Pages i-xix
  2. Pandjassarame Kangueane, Christina Nilofer
    Pages 1-14
  3. Pandjassarame Kangueane, Christina Nilofer
    Pages 15-33
  4. Pandjassarame Kangueane, Christina Nilofer
    Pages 35-54
  5. Pandjassarame Kangueane, Christina Nilofer
    Pages 55-68
  6. Pandjassarame Kangueane, Christina Nilofer
    Pages 69-78
  7. Pandjassarame Kangueane, Christina Nilofer
    Pages 79-86
  8. Pandjassarame Kangueane, Christina Nilofer
    Pages 87-92
  9. Pandjassarame Kangueane, Christina Nilofer
    Pages 93-111
  10. Pandjassarame Kangueane, Christina Nilofer
    Pages 113-124
  11. Pandjassarame Kangueane, Christina Nilofer
    Pages 125-132
  12. Pandjassarame Kangueane, Christina Nilofer
    Pages 133-142
  13. Pandjassarame Kangueane, Christina Nilofer
    Pages 143-146
  14. Pandjassarame Kangueane, Christina Nilofer
    Pages 147-159
  15. Pandjassarame Kangueane, Christina Nilofer
    Pages 161-168
  16. Pandjassarame Kangueane, Christina Nilofer
    Pages 169-178
  17. Pandjassarame Kangueane, Christina Nilofer
    Pages 179-187
  18. Pandjassarame Kangueane, Christina Nilofer
    Pages 189-197
  19. Pandjassarame Kangueane, Christina Nilofer
    Pages 199-201
  20. Pandjassarame Kangueane, Christina Nilofer
    Pages 203-205
  21. Back Matter
    Pages 207-207

About this book

Introduction

This book illustrates the importance and significance of the molecular (physical and chemical) and evolutionary (gene fusion) principles of protein-protein and domain-domain interactions towards the understanding of cell division, disease mechanism and target definition in drug discovery. It describes the complex issues associated with this phenomenon using cutting edge advancement in Bioinformatics and Bioinformation Discovery. The chapters provide current information pertaining to the types of protein-protein complexes (homodimers, heterodimers, multimer complexes) in context with various specific and sensitive biological functions. The significance of such complex formation in human biology in the light of molecular evolution is also highlighted using several examples. The chapters also describe recent advancements on the molecular principles of protein-protein interaction with reference to evolution towards target identification in drug discovery. Finally, the book also elucidates a comprehensive yet a representative description of a large number of challenges associated with the molecular interaction of proteins.

Keywords

Protein-protein interactions domain-domain interactions gene fusion Protein complexes Drug discovery Vaccine development

Authors and affiliations

  • Pandjassarame Kangueane
    • 1
  • Christina Nilofer
    • 2
  1. 1.Biomedical InformaticsPondicherryIndia
  2. 2.School of Bio Sciences and TechnologyVIT UniversityVelloreIndia

Bibliographic information