Regulation of Signal Transduction in Human Cell Research

  • Nariyoshi Shinomiya
  • Hiroaki Kataoka
  • Qian Xie

Part of the Current Human Cell Research and Applications book series (CHCRA)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Zhendong A. Zhong, Nicole J. Ethen, Bart O. Williams
    Pages 1-27
  3. Toshinori Ozaki, Mizuyo Nakamura, Takehiko Ogata, Meijie Sang, Osamu Shimozato
    Pages 85-98
  4. Brian M. Cartwright, Phillip R. Musich, Yue Zou
    Pages 99-127
  5. Nariyoshi Shinomiya, Qian Xie, George F. Vande Woude
    Pages 129-154
  6. Douglas P. Thewke, Jianqun Kou, Makenzie L. Fulmer, Qian Xie
    Pages 155-181
  7. Hiroaki Kataoka, Tsuyoshi Fukushima
    Pages 183-197
  8. Atsushi Yoshimori, Sei-Ichi Tanuma
    Pages 199-218

About this book


This volume focuses on the relationship between the regulation of signal transduction and disease mechanisms, and discusses how the dysregulation of intracellular signals cause diseases, cell death, carcinogenesis, and other disorders.

Growth, survival, transformation, and metabolic activities at the cellular level are regulated by various intracellular signal transduction pathways. Sources that stimulate intracellular signals include intracellular stresses and signal regulators/modulators, as well as extracellular growth factors. Recent studies on signal transduction analysis using animal and human cell lines have revealed how the intracellular signals are regulated and why their dysregulation leads to pathological states such as tumorigenesis, metabolic diseases, cell death, and so on.

This book highlights several important key molecules and intracellular signaling pathways such as microRNA, the TGF-beta signaling pathway, the Wnt signaling pathway and MET signaling pathway as topical and highly relevant issues in human cell research related to signal transduction. In addition to assessing the pathogenic role of these signaling pathways, it focuses on the molecular design of small molecule regulators/inhibitors of said pathways, one of the most important approaches in this area.

This book offers a valuable guide, helping not only research scientists but also clinicians to understand how the dysregulation of intracellular signals leads to diseases.


Signal transduction Carcinogenesis Cell death Molecular design Human cell

Editors and affiliations

  • Nariyoshi Shinomiya
    • 1
  • Hiroaki Kataoka
    • 2
  • Qian Xie
    • 3
  1. 1.Department of Integrative Physiology and Bio-Nano MedicineNational Defense Medical CollegeTokorozawaJapan
  2. 2.Department of PathologyUniversity of MiyazakiMiyazakiJapan
  3. 3.Department of Biomedical SciencesCenter of Excellence for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State UniversityJohnsonUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Nature Singapore Pte Ltd. 2018
  • Publisher Name Springer, Singapore
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-981-10-7295-6
  • Online ISBN 978-981-10-7296-3
  • Series Print ISSN 2522-073X
  • Series Online ISSN 2522-0748
  • Buy this book on publisher's site