DNA Replication

From Old Principles to New Discoveries

  • Hisao Masai
  • Marco Foiani

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1042)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Anna B. Marks, Haiqing Fu, Mirit I. Aladjem
    Pages 43-59
  3. Stephen D. Bell
    Pages 99-115
  4. Joseph L. Stodola, Peter M. Burgers
    Pages 117-133
  5. Agnieszka Gambus
    Pages 163-187
  6. Lin Bai, Zuanning Yuan, Jingchuan Sun, Roxana Georgescu, Michael E. O’Donnell, Huilin Li
    Pages 207-228
  7. Peiyao A. Zhao, Juan Carlos Rivera-Mulia, David M. Gilbert
    Pages 229-257
  8. Marie-Noëlle Prioleau
    Pages 273-286
  9. Kenji Moriyama, Mong Sing Lai, Hisao Masai
    Pages 287-310
  10. Constance Alabert, Zuzana Jasencakova, Anja Groth
    Pages 311-333
  11. Gavin D. Grant, Jeanette G. Cook
    Pages 335-369
  12. Sara Villa-Hernández, Avelino Bueno, Rodrigo Bermejo
    Pages 395-419
  13. Yathish Jagadheesh Achar, Marco Foiani
    Pages 455-487
  14. Wenyi Feng, Arijita Chakraborty
    Pages 489-526
  15. Leonardo K. Teixeira, Steven I. Reed
    Pages 527-547
  16. Advaitha Madireddy, Jeannine Gerhardt
    Pages 549-581

About this book


This book reviews the latest trends and future directions of DNA replication research. The contents reflect upon the principles that have been established through the genetic and enzymatic studies of bacterial, viral, and cellular replication during the past decades. The book begins with a historical overview of the studies on eukaryotic DNA replication by Professor Thomas Kelly, a pioneer of the field. The following chapters include genome-wide studies of replication origins and initiation factor binding, as well as the timing of DNA replications, mechanisms of initiation, DNA chain elongation and termination of DNA replication, the structural basis of functions of protein complexes responsible for execution of DNA replication, cell cycle-dependent regulation of DNA replication, the nature of replication stress and cells’ strategy to deal with the stress, and finally how all these phenomena are interconnected to genome instability and development of various diseases. By reviewing the existing concepts ranging from the old principles to the newest ideas, the book gives readers an opportunity to learn how the classical replication principles are now being modified and new concepts are being generated to explain how genome DNA replication is achieved with such high adaptability and plasticity. With the development of new methods including cryoelectron microscopy analyses of huge protein complexes, single molecular analyses of initiation and elongation of DNA replication, and total reconstitution of eukaryotic DNA replication with purified factors, the field is enjoying one of its most exciting moments, and this highly timely book conveys that excitement to all interested readers.


Replication origins DNA replication initiation factors: DnaA, ORC, MCM Replication timing: TAD, LAD, and Rif1 Chromatin regulation of DNA replication Structures of replication complexes: Cryoelectron microscopy Ubiquitination and SUMOylation of replication factors Replication/transcription collision G-quadruplex and RNA–DNA hybrids Replication fork factors Chromosomal fragile sites Clamp loaders Repetitive DNA elements Genome instability DNA polymerases FEN1

Editors and affiliations

  • Hisao Masai
    • 1
  • Marco Foiani
    • 2
  1. 1.Department of Genome MedicineTokyo Metropolitan Institute of Medical ScienceTokyoJapan
  2. 2.Istituto FIRC di Oncologia MolecolareMilanItaly

Bibliographic information