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Role of Transcription Factors in Gastrointestinal Malignancies

  • Ganji Purnachandra Nagaraju
  • Pallaval Veera  Bramhachari

Table of contents

  1. Front Matter
    Pages i-ix
  2. Pallaval Veera Bramhachari, Ganji Purnachandra Nagaraju
    Pages 1-3
  3. Himanshu Tillu, Ganji Purnachandra Nagaraju
    Pages 5-17
  4. P. S. Sushma, P. UdayKumar, Aliya Sheik
    Pages 19-32
  5. Pallaval Veera Bramhachari, A. M. V. N. Prathyusha, D. Rama Sekhara Reddy
    Pages 33-44
  6. Prudhvi Lal Bhukya, Rongala Laxmivandana, Gopinath Meenakshi Sundaram
    Pages 45-71
  7. A. M. V. N. Prathyusha, Godi Raghu, Pallaval Veera Bramhachari
    Pages 73-89
  8. Shakuntala Mahilkar, Prudhvi Lal Bhukya, L. S. Bhargavi
    Pages 91-100
  9. Neha Merchant, Ganji Lakshmi Vara Prasad, Ganji Purnachandra Nagaraju
    Pages 101-106
  10. Nageswara Rao Reddy Neelapu
    Pages 107-130
  11. Sasidhar Eda, Ramakrishna Vadde, Rajeswari Jinka
    Pages 131-159
  12. Kishore Kumar Jella
    Pages 161-177
  13. Aleem Basha Pinjari, Abdul Razak Meerza
    Pages 179-191
  14. A. M. V. N. Prathyusha, Renuka Nawadkar, Pallaval Veera Bramhachari
    Pages 193-204
  15. Tapan K. Barik, Surya N. Swain
    Pages 205-214
  16. Uday Sankar Allam, Shilpa Kamatham, Maraline Adarsha, Sk. Md. Jasmine, P. V. Giri Prasad
    Pages 215-237
  17. Siva Krishna Prasad Konduru, Ganji Lakshmi Vara Prasad, Neha Merchant, Santoshi Muppala
    Pages 239-248
  18. A. Hartley, H. Wei, L. Prabhu, M. Martin, T. Lu
    Pages 249-262
  19. Ganji Purnachandra Nagaraju, Subasini Pattnaik
    Pages 263-267
  20. Vajravathi Lakkim, Madhava C. Reddy, Durbaka V. R. Prasad, Dakshayani Lomada
    Pages 269-298
  21. I. Vasavi, A. M. V. N. Prathyusha, Malothu Ramesh, K. Satish Kumar, B. Pratap Naidu, Pallaval Veera Bramhachari et al.
    Pages 299-306
  22. Divya Thirumalaipillai Rajendran, Boopathi Subramaniyan, Mathan Ganeshan
    Pages 307-314
  23. Amanda Joy Bastien
    Pages 315-325
  24. Appiya Santharam Madanraj, Saipriya Laxmi Lammata, Ganji Purnachandra Nagaraju
    Pages 327-339
  25. Waaqo B. Daddacha, Allyson E. Koyen, Ashley J. Schlafstein, David S. Yu
    Pages 341-350
  26. Rongala Laxmivandana, Prudhvi Lal Bhukya, Maddala Madhavi
    Pages 351-361
  27. Inagadapa J. N. Padmavathi, Kakarlapudi Ramaneswari, Alavala Matta Reddy
    Pages 363-369
  28. Ganji Purnachandra Nagaraju, Subasini Pattnaik
    Pages 371-378
  29. Prudhvi Lal Bhukya, Divya Aravind Tiraki, Shakuntala Mahilkar
    Pages 379-389
  30. Abdul Rauf, Saeed Ali, Muhammad Talha Khan, Asad-ur-Rahman, Sarfraz Ahmad
    Pages 391-402
  31. Nagendra Sastry Yarla, Olga Sukocheva, Ilaria Peluso, Swathi Putta, Pallaval Veera Bramhachari, Rajesh Yadala et al.
    Pages 403-411
  32. Gangishetti Umesh, Sudarshan Malla
    Pages 413-425
  33. Balney Rajitha, Ganji Purnachandra Nagaraju
    Pages 427-435
  34. Saipriya Lammata, Mundla Srilatha, Ganji Purnachandra Nagaraju
    Pages 437-447
  35. Inho Choi, Saipriya Lammata, Neha Merchant, Dongkyoo Park
    Pages 465-478
  36. Dongkyoo Park, Neha Merchant, Inho Choi
    Pages 479-493
  37. Himanshu Tillu, Pallaval Veera Bramhachari
    Pages 495-508
  38. Ganji Purnachandra Nagaraju, Pallaval Veera Bramhachari, Subasini Pattnaik
    Pages 509-517
  39. Ganji Purnachandra Nagaraju, Pallaval Veera Bramhachari
    Pages E1-E1

About this book

Introduction

This book illustrates the importance of transcription factors in gastrointestinal cancer progression and metastasis with regard to understanding the mechanism and target definition in drug discovery. Further, it describes the complex issues associated with cancer cell growth and metastasis. The respective chapters provide detailed information on the various types of transcription factors (NF-kB, HIF-1, STAT-3, E2F1, and Sp1) and gastric-associated cancers (esophagus, stomach, colorectal, liver and pancreatic cancers) in connection with specific functional studies like cell cycle, angiogenesis, migration, invasion and apoptosis. These transcription factors control the expression of several signaling pathways involved in tumor growth, making them ideal targets for gastrointestinal cancer therapy. In closing, the book provides comprehensive descriptions of the major challenges associated with gastrointestinal cancer therapy.

Keywords

Gastrointestinal maligancies Transcription factors Signaling Pathways Tumor growth Drug targets

Editors and affiliations

  • Ganji Purnachandra Nagaraju
    • 1
  • Pallaval Veera  Bramhachari
    • 2
  1. 1.Department of Hematology and Medical OncologyEmory UniversityAtlantaUSA
  2. 2.Department of BiotechnologyKrishna UniversityMachilipatnamIndia

Bibliographic information