Pathophysiological Aspects of Proteases

  • Sajal Chakraborti
  • Naranjan S. Dhalla

Table of contents

  1. Front Matter
    Pages i-xv
  2. Role of Proteases in the Development of Cancer

    1. Front Matter
      Pages 1-1
    2. Sandra Radenkovic, Kristina Gopcevic, Gordana Konjevic, Vladimir Jurisic
      Pages 3-22
    3. Caroline Coleman-Vaughan, Arijit Mal, Abhijit De, Justin V. McCarthy
      Pages 47-87
    4. Paulo Bastos, Sandra Magalhães, Lúcio Lara Santos, Rita Ferreira, Rui Vitorino
      Pages 89-118
    5. Dalton Dittz Júnior, Fernanda de Oliveira Lemos, Ana Candida Araujo e Silva
      Pages 119-145
    6. Mashenka B. Dimitrova, Dimitrinka Y. Atanasova, Nikolai E. Lazarov
      Pages 147-160
    7. Rajendra K. Sharma, Umashankar Das, Sreejit Parameswaran, Sujeet Kumar, Jonathan R. Dimmock
      Pages 161-170
    8. Sanjeev Kumar Maurya, Nitesh Poddar, Pallavi Tandon, Ajit Kumar Yadav
      Pages 207-236
    9. Poulami Khan, Shruti Banerjee, Apoorva Bhattacharya, Dipanwita Dutta Chowdhury, Apratim Dutta, Tanya Das
      Pages 237-263
    10. Abir K. Panda, Sreeparna Chakraborty, Kirti Kajal, Dia Roy, Tania Sarkar, Gaurisankar Sa
      Pages 265-296
    11. Animesh Chowdhury, Donatella Romaniello, Soma Ghosh, Tapati Chakraborti, Soumitra Roy, Sajal Chakraborti
      Pages 297-317
  3. Role of Proteases in Different Diseases

    1. Front Matter
      Pages 319-319
    2. Fabrizio Bruschi, Barbara Pinto
      Pages 321-352
    3. Mariusz Gogol, Oliwia Bochenska, Marcin Zawrotniak, Justyna Karkowska-Kuleta, Dorota Zajac, Maria Rapala-Kozik
      Pages 353-380
    4. Anna Clara M. Galdino, Marta H. Branquinha, André L. S. Santos, Lívia Viganor
      Pages 381-397
    5. Alexis N. Campetelli, Noelia E. Monesterolo
      Pages 399-422
    6. Snehasikta Swarnakar, Anirban Roy, Satyabrata Ghosh, Rajib Majumder, Sandip Paul
      Pages 489-513
    7. Shatadal Ghosh, Bhawna Pandey, Parames C. Sil
      Pages 515-533
    8. Thomas Divya, Sekar Vasudevan, Ganapasam Sudhandiran
      Pages 535-551
    9. Soumya Chatterjee, Kaustav Chakraborty, Subhabrata Moitra, Arindam Bhattacharyya
      Pages 553-566
    10. Ganapasam Sudhandiran, Srinivasan Kalayarasan, Thomas Divya, Bakthavatchalam Velavan
      Pages 567-581
    11. Sharmistha Banerjee, Sumit Ghosh, Krishnendu Sinha, Parames C. Sil
      Pages 583-603
    12. Gantala Srilatha Reddy, Hanumanth Surekha Rani
      Pages 605-616
    13. Amritlal Mandal, Tapati Chakraborti, Sajal Chakraborti
      Pages 617-634
    14. Sandipan Chakraborty, Soumalee Basu
      Pages 635-645
    15. Tapan Kumar Das
      Pages 647-655
    16. Alok K. Dixit, Pooja Dixit, Ramji L. Sharma
      Pages 657-671
  4. Fabrizio Bruschi, Barbara Pinto
    Pages E1-E1

About this book


This book provides a comprehensive overview of the multifaceted field of protease in the cellular environment and focuses on the recently elucidated functions of complex proteolytic systems in physiology and pathophysiology. Given the breadth and depth of information covered in the respective contributions, the book will be immensely useful for researchers working to identify targets for drug development. Multidisciplinary in scope, the book bridges the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry, making it a thought-provoking read for basic and applied scientists engaged in biomedical research.
Proteases represent one of the largest and most diverse families of enzymes known, and we now know that they are involved in every aspect of a given organism’s life functions. Under physiological conditions, proteases are regulated by their endogenous inhibitors. However, when the activity of proteases is not correctly regulated, disease processes such as tumour progression, vascular remodelling, atherosclerotic plaque progression, ulcer, rheumatoid arthritis, Alzheimer’s disease and inflammation can result. Many infective microorganisms require proteases for replication or use them as virulence factors, which has facilitated the development of protease-targeted therapies for a variety of parasitic diseases.


Protease and antiproteases Neuronal diseases Cancer Cardiovascular diseases Parasitic diseases Gene therapy

Editors and affiliations

  • Sajal Chakraborti
    • 1
  • Naranjan S. Dhalla
    • 2
  1. 1.Department of Biochemistry and BiophysicsUniversity of KalyaniKalyaniIndia
  2. 2.Institute of Cardiovascular SciencesUniversity of ManitobaManitobaCanada

Bibliographic information