Developmental Origins of Health and Disease (DOHaD)

From Biological Basis to Clinical Significance

  • Takeo Kubota
  • Hideoki Fukuoka

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1012)

Table of contents

  1. Front Matter
    Pages i-vii
  2. Biological Basis

    1. Front Matter
      Pages 1-1
    2. Hideoki Fukuoka, Takeo Kubota
      Pages 3-9
    3. Kazuki Mochizuki, Natsuyo Hariya, Takeo Kubota
      Pages 11-18
    4. Koshi Hashimoto, Yoshihiro Ogawa
      Pages 19-25
  3. Disease and Environment

    1. Front Matter
      Pages 27-27
    2. Hiroaki Itoh, Naohiro Kanayama
      Pages 29-39
    3. Yuichiro Arima, Koichi Nishiyama, Yasuhiro Izumiya, Koichi Kaikita, Seiji Hokimoto, Kenichi Tsujita
      Pages 41-48
  4. Transgenerational Mechanism and Its Consequences

    1. Front Matter
      Pages 61-61
    2. Kosuke Taniguchi, Tomoko Kawai, Kenichiro Hata
      Pages 63-73
  5. Clinical Significance

    1. Front Matter
      Pages 83-83

About this book


This book addresses the developmental origins of health and disease (DOHaD), a new medical concept that demonstrates that various adult diseases start in the fetal period. It discusses our current understanding of the molecular mechanisms of DOHaD, including gene body epigenetics and non-coding RNA, and comprehensively examines diseases such type 2 diabetes, a well known as standard DOHaD-associated disease, as well as non-alcoholic fatty liver disease, hypertension and neurodevelopmental disorders. It argues that most adult diseases start at a very early stage, such as in the fetal and neonatal periods, and that earlier prevention and intervention would result in better outcomes for adult diseases such as type 2 diabetes and cardiac disorders, which are increasing in both developed and developing countries. The book appeals to obstetricians and pediatricians, as well as physicians who treat adult patients, wanting to understand the origins of diseases.


Epigenome Pre-emptive medicine Metabolic disease Maternal under-nutrition Nutritional environment

Editors and affiliations

  • Takeo Kubota
    • 1
  • Hideoki Fukuoka
    • 2
  1. 1.Faculty of Child StudiesSeitoku UniversityMatsudoJapan
  2. 2.Research Organization for Nano & Life InnovationWaseda UniversityTokyoJapan

Bibliographic information

  • DOI
  • Copyright Information Springer Nature Singapore Pte Ltd. 2018
  • Publisher Name Springer, Singapore
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-981-10-5525-6
  • Online ISBN 978-981-10-5526-3
  • Series Print ISSN 0065-2598
  • Series Online ISSN 2214-8019
  • Buy this book on publisher's site