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Cellular Osmolytes

From Chaperoning Protein Folding to Clinical Perspectives

  • Laishram Rajendrakumar Singh
  • Tanveer Ali Dar

Table of contents

  1. Front Matter
    Pages i-vii
  2. Pratima Chaudhuri (Chattopadhyay), Naira Rashid, Charu Thapliyal
    Pages 1-34
  3. Fasil Ali, Usma Manzoor, Mudasser Azam, Naseem A. Ansari
    Pages 35-53
  4. Safikur Rahman, Jihyun Park, Jihoe Kim
    Pages 77-96
  5. Garima Chhabra, Nividh Chandra, Rajaram Swaminathan
    Pages 97-119
  6. Mohd Younus Bhat, Laishram Rajendrakumar Singh, Tanveer A. Dar
    Pages 121-142
  7. Tajalli Ilm Chandel, Mohsin Vahid Khan, Rizwan Hasan Khan
    Pages 143-160
  8. Sheeza Khan, Tanveer A. Dar, Laishram Rajendrakumar Singh
    Pages 161-193
  9. Yasanandana Supunsiri Wijayasinghe, Arti Tyagi, Nitesh Kumar Poddar
    Pages 195-228
  10. Iman Dandapath, Megha Chatterjee, Dhoopchhaya Sarkar, Akanksha Gupta, Gulam Rabbani, Rinki Minakshi
    Pages 229-249

About this book

Introduction

This book provides essential insights into improving protein folding/stability, which is a result of the balance between the intra-molecular interactions of protein functional groups and their interactions with the solvent environment.

Even a subtle change in the composition of the solvent environment will alter the fidelity of the protein folding process, and hostile environmental stresses represent one of the basic causes of challenges in protein folding or misfolding.

Among the strategies employed in a wide range of species and cell types to circumvent the hostile environmental conditions is the elaboration of small organic molecules called osmolytes, and recent advances have revealed that certain specific osmolytes might be key biomarkers of cancer, infectious diseases and are useful in heterologous protein expression and vaccine flocculation. As such a large pool of data has been collected regarding their potential for therapeutic intervention in neurodegenerative diseases and other metabolic disorders caused by protein aggregation or proteiostasis failure.

Keywords

Osmolytes Chemical chaperones Protein folding Protein stability Protein misfolding Stress

Editors and affiliations

  • Laishram Rajendrakumar Singh
    • 1
  • Tanveer Ali Dar
    • 2
  1. 1.University of Delhi, Dr. B. R. Ambedkar Center for Biomedical ResearchNew DelhiIndia
  2. 2.Clinical BiochemistryUniversity of KashmirSrinagarIndia

Bibliographic information