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Proteases in Human Diseases

  • Sajal Chakraborti
  • Tapati Chakraborti
  • Naranjan S. Dhalla

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Involvement of Proteases in Various Diseases

    1. Front Matter
      Pages 1-1
    2. Soumitra Roy, Asmita Pramanik, Tapati Chakraborti, Sajal Chakraborti
      Pages 21-40
    3. Cornelia Amalinei, Irina-Draga Căruntu, Simona Eliza Giuşcă, Raluca Anca Balan
      Pages 41-67
    4. Cinthia Figueiredo, Ana Candida Araujo e Silva
      Pages 91-102
    5. Abhijit Sarkar, Sumit Ghosh, Sayanta Dutta, Parames C. Sil
      Pages 131-145
    6. Namrata Singh, Debasish Bhattacharyya
      Pages 147-170
    7. K. Vijaya Rachel, Gandreddi V. D. Sirisha
      Pages 195-226
    8. Sibani Chakraborty, Asim K. Bera, Ankur Chaudhuri, Satyajit Sen
      Pages 227-245
    9. Yashika Rustagi, Aditi Jain, Sharad Saxena, Vibha Rani
      Pages 263-283
    10. Pijush Kanti Pramanik, Dibyendu Paik, Asmita Pramanik, Md Nur Alam, Partha Das, Tapati Chakraborti
      Pages 285-301
    11. Sajal Chakraborti, Jaganmay Sarkar, Pijush Kanti Pramanik, Tapati Chakraborti
      Pages 333-374
    12. Siddavaram Nagini, Satwinderjeet Kaur
      Pages 375-393
    13. Ramesh Prasad, Abhishek Roy, Prosenjit Sen
      Pages 395-408
  3. Role of Proteases in Cardiovascular Diseases

    1. Front Matter
      Pages 409-409
    2. Brittany A. Potz, M. Ruhul Abid, Frank W. Sellke
      Pages 411-423
    3. Gundapaneni Kishore Kumar, Hanumanth Surekha Rani
      Pages 463-471
    4. Veena Dhawan, Riyaz Ahmad Rather
      Pages 473-496
    5. Sharad Saxena, Yashika Rustagi, Aditi Jain, Sonali Dubey, Vibha Rani
      Pages 497-513

About this book

Introduction

This book bridges the gap between fundamental research and biomedical and pharmacological applications on proteases. It represents a comprehensive overview of the multifaceted field of proteases in cellular environment and highlights the recently elucidated functions of complex proteolytic systems in different diseases. Several established investigators have elucidated the crucial role of proteases in biological processes, including how proteolytic function and regulation can be combined to develop new strategies of therapeutic interventions.

Proteases form one of the largest and most diverse families of enzymes known. It is now clear that proteases are involved in every aspect of life functions of an organism. Under physiological conditions, proteases are regulated by their endogenous inhibitors; however, when the activity of proteases is not regulated appropriately, disease processes can result in. So, there is absolute need for a stringent control of proteolytic activities in cells and tissues.

Dysregulation of proteases may cause derangement of cellular signalling network resulting in different pathophysiological conditions such as vascular remodelling, atherosclerotic plaque progression, ulcer and rheumatoid arthritis, Alzheimer disease, cancer metastasis, tumor progression and inflammation. Additionally, many infective microorganisms require proteases for replication or use proteases as virulence factors, which have facilitated the development of protease-targeted therapies for a variety of parasitic diseases.

Keywords

Proteases Human Diseases Cancer Pharceutical Medicine

Editors and affiliations

  • Sajal Chakraborti
    • 1
  • Tapati Chakraborti
    • 2
  • Naranjan S. Dhalla
    • 3
  1. 1.Department of Biochemistry and BiophysicsUniversity of KalyaniKalyaniIndia
  2. 2.Department of Biochemistry and BiophysicsUniversity of KalyaniKalyaniIndia
  3. 3.Department of Physiology, Faculty of Medicine, St. Boniface General Hospital, Institute of Cardiovascular SciencesUniversity of ManitobaWinnipegCanada

Bibliographic information