Hyperthermic Oncology from Bench to Bedside

  • Satoshi Kokura
  • Toshikazu Yoshikawa
  • Takeo Ohnishi

Table of contents

  1. Front Matter
    Pages i-x
  2. Basic Science in Cultured Cells

  3. Basic Science in Whole Body

    1. Front Matter
      Pages 125-125
    2. Hiroshi Terunuma
      Pages 127-135
    3. Takeshi Kobayashi, Akira Ito, Hiroyuki Honda
      Pages 137-150
    4. Shin-ichiro Masunaga
      Pages 151-169
  4. Clinical Science in Cancer Patients

    1. Front Matter
      Pages 171-171
    2. Takayuki Ohguri
      Pages 173-176
    3. Daigo Yamamoto, Chizuko Yamamoto, Satoru Iwase, Hiroki Odagiri
      Pages 201-207
    4. Hisaki Aiba, Hiroaki Kimura, Takanobu Otsuka
      Pages 227-243
    5. Daigo Yamamoto, Chizuko Yamamoto, Satoru Iwase, Hiroki Odagiri
      Pages 249-255
    6. Takayuki Asao, Hiroyuki Kuwano, Takeo Takahashi, Takashi Nakano
      Pages 295-308
    7. Hiroshi Terunuma, Noriyuki Nishino, Tsuyoshi Abe, Akiko Yoshimura, Atsushi Toki, Tatsuaki Ishiguro et al.
      Pages 309-318
    8. Yutaka Yonemura, Akiyoshi Mizumoto, Haruaki Ishibashi, Kazuyoshi Takeshita, Oliver Glehen, Paul H. Sugarbaker
      Pages 371-396
    9. Kagayaki Kuroda
      Pages 397-420
    10. Masahiro Kuroda, Kazuyuki Saito, Koichi Ito, Shin-ichiro Umemura
      Pages 421-437
    11. Takeo Ohnishi
      Pages 439-444

About this book


This comprehensive work broadens readers' understanding of the rudimentary mechanism of the anti-cancer effect of hyperthermia. It also presents state-of-the-art clinical outcomes by hyperthermia treatment of cancer.

In the past few decades, basic and clinical research have shown through in vitro experiments that hyperthermia inhibits epithelial-mesenchymal transition (EMT), resulting in the prevention of metastasis. It also has been learned that hyperthermia shows its superior benefit when applied in combination with radiation therapy, chemotherapy, or various immunotherapies as treatments of several types of carcinoma. The chapters here from expert contributors describe the details of their research for each type of cancer.

This book provides not only an overview and the current status of hyperthermia but also its future perspectives. Therefore this volume will greatly benefit oncologists, radiologists and radiology technologists, and chemotherapists who are involved in immunotherapy for all kinds of cancer.


Anti-cancer Chemotherapy Epithelial-mesenchymal transition Heat Shock Protein Hyperthermic treatment Immunotherapy

Editors and affiliations

  • Satoshi Kokura
    • 1
  • Toshikazu Yoshikawa
    • 2
  • Takeo Ohnishi
    • 3
  1. 1.Kokura Lab, Health and Medical SciencesKyoto Gakuen UniversityKyotoJapan
  2. 2.Department of Inflammation and ImmunologKyoto Prefectural University of MedicineKyotoJapan
  3. 3.Department of Radiation OncologyNara Medical UniversityKashihara, NaraJapan

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media Singapore 2016
  • Publisher Name Springer, Singapore
  • eBook Packages Medicine
  • Print ISBN 978-981-10-0717-0
  • Online ISBN 978-981-10-0719-4
  • Buy this book on publisher's site