Single Cell Sequencing and Systems Immunology

  • Xiangdong Wang

Part of the Translational Bioinformatics book series (TRBIO, volume 5)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Mengjia Qian, Duojiao Wu, Ding Zhang, Jian Wang, Yunfeng Cheng, Xiangdong Wang
    Pages 1-10
  3. Julián Candia, Jayanth R. Banavar, Wolfgang Losert
    Pages 11-30
  4. Ying Chen, Fengping Wang
    Pages 31-40
  5. Kenian Chen, Xiaomin Dong, Jiaqian Wu
    Pages 41-63
  6. Xuerui Luo, Andy Tsun, Jing Yang, Zuojia Chen, Yayi Gao, Kongchen Li et al.
    Pages 73-93
  7. Lingyan Wang, Fuping Wang, Jieyi Shi, Xiangdong Wang
    Pages 95-109
  8. Mengjia Qian, Claudio Spada, Xiangdong Wang
    Pages 111-122
  9. Xiaojing Xu, William C. S. Cho, Jinglin Xia
    Pages 123-141
  10. Mitchell R. McGill, Hartmut Jaeschke
    Pages 143-154
  11. Jian Wang, Zhihui Min, Meiling Jin, Xiangdong Wang
    Pages 155-163
  12. Mingyan He, Li Feng, Jinglin Xia
    Pages 175-177

About this book


The volume focuses on the genomics, proteomics, metabolomics, and bioinformatics of a single cell, especially lymphocytes and on understanding the molecular mechanisms of systems immunology. Based on the author’s personal experience, it provides revealing insights into the potential applications, significance, workflow, comparison, future perspectives and challenges of single-cell sequencing for identifying and developing disease-specific biomarkers in order to understand the biological function, activation and dysfunction of single cells and lymphocytes and to explore their functional roles and responses to therapies. It also provides detailed information on individual subgroups of lymphocytes, including cell characters, function, surface markers, receptor function, intracellular signals and pathways, production of inflammatory mediators, nuclear receptors and factors, omics, sequencing, disease-specific biomarkers, bioinformatics, networks and dynamic networks, their role in disease and future prospects.


Dr. Xiangdong Wang is a Professor of Medicine, Director of Shanghai Institute of Clinical Bioinformatics, Director of Fudan University Center for Clinical Bioinformatics, Director of the Biomedical Research Center of Zhongshan Hospital, Deputy Director of Shanghai Respiratory Research Institute, Shanghai, China.



Cell biology Immunotherapy Lymphoid dendritic cells Systems Immunology Systems medicine lymphocytes

Editors and affiliations

  • Xiangdong Wang
    • 1
  1. 1.Zhongshan Hospital Fudan UniversityShanghaiChina

Bibliographic information