Circulating Nucleic Acids in Early Diagnosis, Prognosis and Treatment Monitoring

An Introduction

  • Peter B. Gahan

Part of the Advances in Predictive, Preventive and Personalised Medicine book series (APPPM, volume 5)

Table of contents

  1. Front Matter
    Pages i-xix
  2. Background

    1. Front Matter
      Pages 1-1
    2. Peter B. Gahan
      Pages 15-41
  3. Methodology

    1. Front Matter
      Pages 43-43
    2. Safia El Messaoudi, Alain R. Thierry
      Pages 45-69
    3. Alain R. Thierry, Safia El Messaoudi, Evelyne Lopez-Crapez
      Pages 71-87
    4. Florent Mouliere, Alain R. Thierry, Christian Larroque
      Pages 89-111
    5. Wenying Pan, Stephen R. Quake
      Pages 113-139
  4. Applications

    1. Front Matter
      Pages 141-141
    2. Heidi Schwarzenbach
      Pages 143-163
    3. Stephanie Cheuk Yin Yu
      Pages 165-212
    4. Asif Butt, Ramasamyiyer Swaminathan
      Pages 213-237
    5. Michael Fleischhacker, Bernd Schmidt
      Pages 239-293
    6. Lisa Hui, Jill L. Maron, Peter B. Gahan
      Pages 295-323
    7. Stefan Holdenrieder
      Pages 325-367
  5. Other Aspects

    1. Front Matter
      Pages 369-369
    2. Rob Elles, Simon Patton, Outi Kamarainen, Zandra Deans
      Pages 371-380
    3. Celine Lewis, Lyn S. Chitty
      Pages 381-398
  6. Back Matter
    Pages 399-471

About this book


DNA and RNA fractions can be isolated from a variety of body fluids including whole blood, serum, plasma, urine, saliva and cerebrospinal fluid from both patients and healthy individuals.  Such isolates can be exploited in the early detection of clinical disorders, stratification of patients for treatment, treatment monitoring and clinical follow-up.  In addition, the use in fetal medicine allows the early detection of fetal sex, Rh factor and aneuploid disorders as well as following both fetal and premature born infant development. This volume is intended as a primer for those who are interested in entering the field of circulating nucleic acids.

The areas covered in this volume include:

·      Background and general biology of circulating nucleic acids

·      Methodology

·      Applications of circulating nucleic acids

·      Quality Assurance

·      Ethics


cancer circulating nucleic acids diabetes fetal CNAPS methodology

Editors and affiliations

  • Peter B. Gahan
    • 1
  1. 1.Anatomy & Human SciencesKing's College LondonLondonUnited Kingdom

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media Dordrecht 2015
  • Publisher Name Springer, Dordrecht
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-94-017-9167-0
  • Online ISBN 978-94-017-9168-7
  • Series Print ISSN 2211-3495
  • Series Online ISSN 2211-3509
  • Buy this book on publisher's site