Translation and Its Regulation in Cancer Biology and Medicine

  • Armen Parsyan

Table of contents

  1. Front Matter
    Pages i-xxxiv
  2. Armen Parsyan
    Pages 1-3
  3. Translation Machinery in Cancer

    1. Front Matter
      Pages 5-5
    2. Nancy Villa, Christopher S. Fraser
      Pages 7-37
    3. Nancy Villa, Christopher S. Fraser
      Pages 39-71
    4. Nathaniel Robichaud, Nahum Sonenberg
      Pages 73-113
    5. David Shahbazian, Jerry Pelletier, Yuri Svitkin, John W. B. Hershey, Armen Parsyan
      Pages 115-134
    6. Hsin-Sheng Yang, Qing Wang, Magdalena M. Bajer, Tobias Schmid
      Pages 135-161
    7. Simon D. Wagner, Anne E. Willis, Daniel Beck
      Pages 163-171
    8. John W. B. Hershey
      Pages 173-194
    9. Bertal H. Aktas, Ting Chen
      Pages 195-221
    10. Myung Hee Park, Swati Mandal, Ajeet Mandal, Edith C Wolff
      Pages 223-232
    11. Stefano Biffo, Daniela Brina, Stefania Oliveto
      Pages 233-240
    12. Bruna Scaggiante, Barbara Dapas, Rossella Farra, Federica Tonon, Michela Abrami, Mario Grassi et al.
      Pages 241-265
    13. Sara Ricciardi, Fabrizio Loreni
      Pages 267-278
    14. Gabriela Galicia-Vázquez, Jerry Pelletier
      Pages 279-304
  4. Regulation of Translation by Signaling Pathways in Cancer

    1. Front Matter
      Pages 305-305
    2. Yoshinori Tsukumo, Mathieu Laplante, Armen Parsyan, Davide Ruggero, Bruno Fonseca
      Pages 307-343
    3. Mario Pende, Caroline Treins
      Pages 345-362
    4. Luc Furic, Emma Beardsley, Ivan Topisirovic
      Pages 363-374
  5. Cell Fate and Translation in Cancer

    1. Front Matter
      Pages 375-375
    2. Svetlana Avdulov, José R. Gómez-García, Peter B. Bitterman, Vitaly A. Polunovsky
      Pages 377-394
    3. Martin Holcik
      Pages 395-420
    4. Tingfang Yi, Gerhard Wagner
      Pages 421-432
  6. Translation and its Regulation by Cancer Types

    1. Front Matter
      Pages 433-433
    2. Armen Parsyan, Ryan J. Sullivan, Ari-Nareg Meguerditchian, Sarkis Meterissian
      Pages 435-452
    3. Armen Parsyan, James L. Chen, Raphael Pollock, Sarkis Meterissian
      Pages 453-466
    4. Markus Reschke, Nina Seitzer, John G. Clohessy, Pier Paolo Pandolfi
      Pages 467-486
    5. Armen Parsyan, Justin G. Meyerowitz, William A. Weiss
      Pages 487-497
    6. Cherie-Ann O. Nathan, Oleksandr Ekshyyan, Arunkumar Anandharaj
      Pages 499-512
    7. Armen Parsyan, Ana Maria Gonzalez-Angulo, Dimitrios Zardavas, Martine Piccart, Sarkis Meterissian
      Pages 513-555
    8. Armen Parsyan, Karen L. Reckamp
      Pages 557-574
    9. Armen Parsyan, Lorenzo Ferri
      Pages 575-591
    10. Armen Parsyan, Nathaniel Robichaud, Sarkis Meterissian
      Pages 593-610
    11. Jennifer A. Sanders, Philip A. Gruppuso
      Pages 611-629
    12. Mamatha Bhat, Peter Metrakos, Santiago Ramon y Cajal, Nahum Sonenberg, Tommy Alain
      Pages 631-643
    13. Armen Parsyan, Susana Banerjee
      Pages 645-656
    14. Nina Seitzer, Markus Reschke, John G. Clohessy, Pier Paolo Pandolfi
      Pages 657-672
    15. Armen Parsyan, Emmanuel Seront, Jean-Pascal Machiels
      Pages 673-680
  7. Back Matter
    Pages 681-697

About this book


This book, for the first time, comprehensively assembles and analyzes a large body of information on the role of the fundamental mechanism of the protein biosynthesis pathway, translation, in cancer biology. It systematically explores the function of the translation machinery and its regulation, including cell signaling, in the development, maintenance and progression of human cancer. The work presented here unveils the tremendous potential and applications of this vast and exciting branch of genetic, biochemical and molecular science in cancer medicine and drug development.

Chapters contributed by experts in the field take the reader on a journey that starts with a dissection of the translation machinery and its regulation in norm and cancer. Later chapters characterize etiological and pathogenetic roles that translation plays in specific cancer types. Various aspects of diagnostic, prognostic and therapeutic significance of the translation machinery and its control in cancer are discussed. Readers will discover the importance of the process of translation and its regulatory mechanisms in physiology and cancer biology. 

The chapters and the numerous illustrations included here were contributed by expert scientists and clinicians from renowned academic and clinical establishments in Canada, the United States of America, the United Kingdom, Italy, France, Belgium, Spain, Germany and Australia.  

The book conveys information and knowledge that may interest a broad range of students and scholars ranging from basic scientists to clinicians and drug developers seeking to better understand the protein synthesis and its aberrations in cancer biology and cancer medicine.  



Cancer Cancer treatment and diagnostics Protein synthesis Signalling Translation

Editors and affiliations

  • Armen Parsyan
    • 1
  1. 1.SurgeryMcGill UniversityMontrealCanada

Bibliographic information