Stem Cells in Cancer: Should We Believe or Not?

  • Enrique Grande
  • Luis Antón Aparicio

Table of contents

  1. Front Matter
    Pages i-viii
  2. Guadalupe Aparicio Gallego, Enrique Grande, Luis Antón Aparicio
    Pages 1-22
  3. Laura Visa, Cristina Nadal, Pere Gascon
    Pages 67-84
  4. Antonio Barbáchano, María Jesús Larriba, Gemma Ferrer-Mayorga, Alberto Muñoz, José Manuel González-Sancho
    Pages 85-106
  5. Pîlar Eroles, Jose A. Perez-Fidalgo, Ana Lluch
    Pages 107-126
  6. Esther Uña Cidón, Tamas Hickish
    Pages 127-147
  7. Luís León Mateos, Martín Lázaro Quintela, Sergio Vázquez Estévez, Luis Antón Aparicio
    Pages 149-165
  8. Jorge Alberto Guadarrama-Orozco, Erika Ruiz-Garcia, Juan Carlos Casarez-Price, Samuel Rivera-Rivera, Horacio Astudillo-de la Vega
    Pages 167-189
  9. José David Gómez Rangel
    Pages 191-202
  10. Ainara Soria, Jacobo Muñoz del Toro, Raquel Fuentes, Alfonso Cortés
    Pages 203-228
  11. Fernando Hurtado de Mendoza, Enrique Alanya Rodriguez
    Pages 229-243
  12. Andrés Felipe Cardona, Jairo Zuluaga, Hernán Carranza, Jorge Miguel Otero, Carlos Vargas, León Darío Ortiz
    Pages 245-261
  13. Juan Carlos Mellídez Barroso, Maria C. Santos
    Pages 263-290
  14. Back Matter
    Pages 291-299

About this book


This volume explores the latest developments in a novel area of molecular biology and a hot topic in the field of oncology: cancer stem cells. These chapters from expert contributing authors present concepts such as the universal stem cell, new molecular pathways, new targeted agents, the different roles that cancer stem cells seem to have according to the organ they are placed in, and the future role that targeting cancer stem cells may have in the management of patients in the clinic.   

Exploring the latest research including new data from randomized trials, this book examines important proposals over the origin of cancer stem cells such as the possibility that cancer stem cells may arise from mutated stem cells or a fully differentiated cell that may undergo several mutations that drive it back to a stem-like state. The authors consider the role that stem cells seem to have in the onset, development and resistance to classical antitumoral treatments of cancer and discuss possible potential future treatment modalities for the management of advanced cancer patients. 

The question, "Are stem cells involved in cancer?" may not have a simple answer, but ongoing investigations, in-depth consideration and a broad spectrum of information can be found in this book, allowing the reader to arrive at his or her own answer.  

This book will appeal to researchers in the field of oncology and cancer research and biomedical scientists with an interest in stem cells.


Hedgehog Notch Wnt cancer biology cancer stem cells

Editors and affiliations

  • Enrique Grande
    • 1
  • Luis Antón Aparicio
    • 2
  1. 1.Medical OncologyRamón y Cajal University HospitalMadridSpain
  2. 2.Medical OncologyComplejo Hospitalario Universitario A CoruñaA CoruñaSpain

Bibliographic information