Probiotics 3

Immunomodulation by the Gut Microflora and Probiotics

  • R. Fuller
  • G. Perdigon

Table of contents

  1. Front Matter
    Pages I-11
  2. M. E. Roux, M. C. del Lopez, A. Florin-Christensen
    Pages 12-28
  3. J. Ronco, B. Guy
    Pages 29-68
  4. C. B. M. Maassen, J. D. Laman, W. J. A. Boersma, E. Claassen
    Pages 176-192
  5. C. Matar, J. Goulet, R. L. Bernier, E. Brochu
    Pages 193-212
  6. G. Perdigón, A. Pesce de Ruiz Holgado
    Pages 213-233
  7. G. Perdigón, R. Fuller
    Pages 271-273
  8. Back Matter
    Pages 274-276

About this book


The way in which probiotics work is still not clearly defined, but it is becoming more and more apparent that immune stimulation is an important feature in some of the observed effects. In the previous two books in this series the scientific basis and the practical applications were considered. It seemed that the immunogenic potential of probiotics merited a book of its own with experts from all over the world covering the general effect of the gut microflora on immunity as well as the particular response that pro biotic microorganisms generate. The importance of immune stimulation by probiotic organisms cannot be overemphasised. It opens up the technique for use, not only as a treatment for intestinal diseases, but also as a treatment that could be effective against infections outside the gastrointestinal tract. This book considers how the body reacts to the presence of orally administered microorganisms (normally lactic acid bacteria). The responses may be in the form of antibodies (lgA, IgG, IgM), cytokines, killer cells or macrophage activity. Do these responses result in antagonism of the stimulating bacteria, do they affect the composition of the indigenous gut microflora and are they sufficienty strong to kill bacterial pathogens or tumour cells? Where we have answers these will be reported and discussed; where there are no answers there will be speculation and prediction.


bacteria cytokine food immune system microorganism probiotic probiotics vaccine

Editors and affiliations

  • R. Fuller
    • 1
  • G. Perdigon
    • 2
  1. 1.Gut MicroecologyReadingUK
  2. 2.Tucumán UniversityArgentina

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media B.V. 2000
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-90-481-5429-6
  • Online ISBN 978-94-017-2768-6
  • Buy this book on publisher's site