Multiple Drug Resistance in Cancer 2

Molecular, Cellular and Clinical Aspects

  • Martin Clynes

Table of contents

  1. Front Matter
    Pages i-xi
  2. Irene Bosch, James M. Croop
    Pages 1-30
  3. Ursula A. Germann, Timothy C. Chambers
    Pages 31-60
  4. András Váradi, Gábor E. Tusnády, Éva Bakos, Balázs Sarkadi
    Pages 71-79
  5. Toshihisa Ishikawa, M. Tien Kuo, Kyoji Furuta, Masaaki Suzuki
    Pages 81-93
  6. Giuseppe Arancia, Annarica Calcabrini, Stefania Meschini, Agnese Molinari
    Pages 95-111
  7. Daragh Byrne, Carmel Daly, Roisin NicAmhlaoibh, Anthony Howlett, Kevin Scanlon, Martin Clynes
    Pages 113-136
  8. Miguel A. Izquierdo, George L. Scheffer, Anouk B. Schroeijers, Mariska C. de Jong, Rik J. Scheper
    Pages 137-148
  9. Ralph E. Parchment, Augusto Pessina
    Pages 149-164
  10. G. Damia, M. D’Incalci
    Pages 165-173
  11. Mark R. Müller, Jürgen Thomale, Manfred F. Rajewsky, Siegfried Seeber
    Pages 175-185
  12. Martin G. Rumsby, Lisa Drew, J. Roger Warr
    Pages 203-224
  13. Bruno Chauffert, Marie-Thérèse Dimanche-Boitrel, Carmen Garrido, Mikael Ivarsson, Monique Martin, François Martin et al.
    Pages 225-235
  14. Ross Davey, Mary Davey
    Pages 237-247
  15. Jürgen Mattern, Manfred Volm
    Pages 249-256
  16. Kathleen W. Scotto, David A. Egan
    Pages 257-269
  17. Ulrike Stein, Wolfgang Walther
    Pages 271-282
  18. Tetsuo Mashima, Hiroyuki Seimiya, Zhihong Chen, Shiro Kataoka, Takashi Tsuruo
    Pages 293-308
  19. Noel Daly, Paula Meleady, Derek Walsh, Martin Clynes
    Pages 321-344

About this book


Resistance to chemotherapy, and especially multi-drug resistance, represents a significant barrier to the successful treatment of cancer. This multi-author volume brings together a wide range of up-to-date reviews on different aspects of our knowledge of drug-resistance mechanisms, written by experts in the different areas. Particular attention is paid to recently discovered mechanisms relating to oncogene expression and in particular to proteins involved in regulation and execution of apoptosis. Other important topics covered include DNA repair, topoisomerases, cell cycle control, oxygenation and vascularisation of tumours, LRP, intermediate filament proteins and low-level resistance. Recent developments in understanding the role of efflux pumps (P-170, MRP) in multi-drug resistance are also reviewed. This book will be useful to clinicians and scientists working in the areas of chemotherapy, drug resistance, DNA repair and apoptosis research.


DNA Nucleotide apoptosis gene expression proteins transcription

Editors and affiliations

  • Martin Clynes
    • 1
  1. 1.National Cell & Tissue Center, Bioresearch IrelandDublin City UniversityGlasnevin, DublinIreland

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media B.V. 1998
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-90-481-5108-0
  • Online ISBN 978-94-017-2374-9
  • Buy this book on publisher's site