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Genetics and Evolution of Aging

  • Michael R. Rose
  • Caleb E. Finch

Part of the Contemporary Issues in Genetics and Evolution book series (CIGE, volume 3)

Table of contents

  1. Front Matter
    Pages I-2
  2. General perspectives on aging

    1. Front Matter
      Pages 3-4
    2. Michael R. Rose, Caleb E. Finch
      Pages 5-12
    3. Brian Charlesworth
      Pages 13-21
  3. Diversity of aging

  4. Aging in Drosophila

    1. Front Matter
      Pages 107-108
    2. L. Partridge, N. H. Barton
      Pages 109-118
    3. Joseph L. Graves Jr., Laurence D. Mueller
      Pages 119-129
    4. Robert H. Tyler, Hardip Brar, Meena Singh, Amparo Latorre, Joseph L. Graves, Laurence D. Mueller et al.
      Pages 161-167
    5. James E. Fleming, Greg S. Spicer, Roger C. Garrison, Michael R. Rose
      Pages 199-214
  5. Aging in mammals

About this book

Introduction

Aging is one of those subjects that many biologists feel is largely unknown. Therefore, they often feel comfortable offering extremely facile generalizations that are either unsupported or directly refuted in the experimental literature. Despite this unfortunate precedent, aging is a very broad phenomenon that calls out for integration beyond the mere collecting together of results from disparate laboratory organisms. With this in mind, Part One offers several different synthetic perspectives. The editors, Rose and Finch, provide a verbal synthesis of the field that deliberately attempts to look at aging from both sides, the evolutionary and the molecular. The articles by Charlesworth and Clark both provide population­ genetic perspectives on aging, the former more mathematical, the latter more experimental. Bell takes a completely different approach, arguing that aging may not be the result of evolutionary forces. Bell's model instead proposes that aging could arise from the progressive deterioration of chronic host­ pathogen interactions. This is the first detailed publication of this model. It marks something of a return to the type of aging theories that predominated in the 1950's and 1960's, theories like the somatic mutation and error catastrophe theories. We hope that the reader will be interested by the contrast in views between the articles based on evolutionary theory and that of Bell. MR. Rose and C. E. Finch (eds. ), Genetics and Evolution of Aging, 5-12, 1994. © 1994 Kluwer Academic Publishers. The J aniform genetics of aging 2 Michael R. Rosel & Caleb E.

Keywords

Allele Elongation Mutation evolution evolutionary biology genes genetics molecular biology mutant saccharomyces cerevisiae

Editors and affiliations

  • Michael R. Rose
    • 1
  • Caleb E. Finch
    • 2
  1. 1.University of CaliforniaIrvineUSA
  2. 2.University of Southern CaliforniaLos AngelesUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-017-1671-0
  • Copyright Information Springer Science+Business Media B.V. 1994
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-90-481-4416-7
  • Online ISBN 978-94-017-1671-0
  • Series Print ISSN 0929-712X
  • Buy this book on publisher's site