Cerebral Amyloid Angiopathy in Alzheimer’s Disease and Related Disorders

  • Marcel M. Verbeek
  • Robert M. W. de Waal
  • Harry V. Vinters

Table of contents

  1. Front Matter
    Pages i-xix
  2. Clinical Aspects of CAA and CAA-Related Hemorrhage

  3. Genetics of CAA

    1. Front Matter
      Pages 79-79
    2. Mark O. McCarron, James A. R. Nicoll
      Pages 81-102
    3. Marjolijn Bornebroek, Joost Haan, Egbert Bakker, Raymund A. C. Roos
      Pages 103-119
    4. Ísleifur Ólafsson, Leifur Thorsteinsson
      Pages 121-134
  4. Cellular and Molecular Pathology of CAA

    1. Front Matter
      Pages 135-135
    2. Harry V. Vinters, Jean-Paul G. Vonsattel
      Pages 137-155
    3. Alex E. Roher, Yu-Min Kuo, Alexander A. Roher, Mark R. Emmerling, Warren J. Goux
      Pages 157-177
    4. Haruyasu Yamaguchi, Marion L. C. Maat-Schieman
      Pages 179-188
    5. Robert M. W. De Waal, Marcel M. Verbeek
      Pages 207-221
    6. Marion L. C. Maat-Schieman, Sjoerd G. Van Duinen, Remco Natté, Raymund A. C. Roos
      Pages 223-236
    7. Bernardino Ghetti, Pedro Piccardo, Blas Frangione, Rubén Vidal, Jorge Ghiso
      Pages 237-247
  5. In Vitro and Animal Models of CAA

    1. Front Matter
      Pages 249-249
    2. Marcel M. Verbeek, William E. Van Nostrand, Robert M. W. De Waal
      Pages 265-279
    3. Daniel Paris, Terrence Town, Michael Mullan
      Pages 281-294
    4. Greg M. Cole, Fusheng Yang
      Pages 295-311
    5. Berislav V. Zlokovic, Jorge Ghiso, Blas Frangione
      Pages 325-346
  6. Back Matter
    Pages 347-357

About this book


Cerebral amyloid angiopathy (CAA) is a distinctive abnormality of small cerebral blood vessels, one that has intrigued neuroscientists for decades. The time seems right for a book which examines the phenomenon of CAA using a multifaceted approach: What does it produce clinically? How might CAA be imaged? What are the crucial biochemical/cellular events within cerebral vessel walls that lead to CAA? How can in vitro or transgenic experimental systems be used to understand the etiology of, or even potential treatments for, CAA? The editors have assembled key figures in the field of CAA research to examine these (and other) questions in a series of focused chapters that address specific issues of importance in understanding CAA and its clinical manifestations. Comprehending the biology and pathogenesis of this fascinating vascular lesion may even provide clues to less common forms of cerebral microvascular disease that have been recognized for decades (hypertensive microangiopathy) or more recently (CADASIL).


Alzheimer Grading Lipoprotein alzheimer's disease brain genetics hereditary cerebral hemorrhage molecular pathology muscle neuropathology pathogenesis vascular disease

Editors and affiliations

  • Marcel M. Verbeek
    • 1
  • Robert M. W. de Waal
    • 2
  • Harry V. Vinters
    • 3
  1. 1.Departments of Neurology and PathologyUniversity Medical Center St. RadboudNijmegenThe Netherlands
  2. 2.Department of PathologyUniversity Medical Center St. RadboudNijmegenThe Netherlands
  3. 3.UCLA Medical CenterLos AngelesUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media B.V. 2000
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-90-481-5480-7
  • Online ISBN 978-94-017-1007-7
  • Buy this book on publisher's site