Radiopharmaceuticals for Positron Emission Tomography

Methodological Aspects

  • Gerhard Stöcklin
  • Victor W. Pike

Part of the Developments in Nuclear Medicine book series (DNUM, volume 24)

Table of contents

  1. Front Matter
    Pages i-xix
  2. Syed M. Qaim, John C. Clark, Christian Crouzel, Marcel Guillaume, Hans J. Helmeke, Bruno Nebeling et al.
    Pages 1-43
  3. Christian Crouzel, John C. Clark, Claude Brihaye, Bengt Långström, Christian Lemaire, Geerd J. Meyer et al.
    Pages 45-89
  4. Geerd-J. Meyer, Heinz H. Coenen, Stephen L. Waters, Bengt Långström, Robert Cantineau, Karel Strijckmans et al.
    Pages 91-150
  5. Bernard Mazière, Robert Cantineau, Heinz H. Coenen, Marcel Guillaume, Christer Halldin, André Luxen et al.
    Pages 151-178
  6. Back Matter
    Pages 179-180

About this book


Radiochemical methodology constitutes the most important base for the successful functioning of a PET group in the routine production and development of radiopharmaceuticals. Of the several hundred products which have been labelled with positron emitters during the past two decades about 35 are presently considered to be of major interest. The time for a state-of-the-art review is right, since this field has advanced over the past fifteen years to reach a level where guidelines can now be suggested. Chapters of this book deal with each of the main methodological aspects of the chemistry needed to develop an effective radiopharmaceutical, namely radionuclide production, automation and metabolite analysis. A further chapter on QA/QC is written by a broadly-based expert group and is meant to provide a guideline and a base for future monographs and regulations on major PET radiopharmaceuticals of today.
This book will help the increasing numbers of scientists who are now entering the field of PET to appreciate the methodological aspects that are normally addressed by chemists in relation to PET radiopharmaceuticals; it provides many useful practical guidelines and will promote early success in their own endeavours, since these will often necessarily begin by establishing chemical methodology of the kind discussed here.


PET base chemistry development metabolism methodology plasma positron emission tomography (PET) production quality quality assurance quality control radioactivity regulation tomography

Editors and affiliations

  • Gerhard Stöcklin
    • 1
  • Victor W. Pike
    • 2
  1. 1.Institut für NuklearchemieForschungszentrum Jülich GmbHJülichGermany
  2. 2.MRC Cyclotron UnitHammersmith HospitalLondonUK

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media B.V. 1993
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-90-481-4285-9
  • Online ISBN 978-94-015-8204-9
  • Buy this book on publisher's site