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Auto-Immunity and Auto-Immune Disease

A survey for physician or biologist

  • Authors
  • Macfarlane Burnet

Table of contents

  1. Front Matter
    Pages i-ix
  2. Macfarlane Burnet
    Pages 1-8
  3. Macfarlane Burnet
    Pages 9-32
  4. Macfarlane Burnet
    Pages 33-57
  5. Macfarlane Burnet
    Pages 59-71
  6. Macfarlane Burnet
    Pages 73-85
  7. Macfarlane Burnet
    Pages 87-96
  8. Macfarlane Burnet
    Pages 97-107
  9. Macfarlane Burnet
    Pages 109-119
  10. Macfarlane Burnet
    Pages 121-129
  11. Macfarlane Burnet
    Pages 131-151
  12. Macfarlane Burnet
    Pages 153-171
  13. Macfarlane Burnet
    Pages 173-190
  14. Macfarlane Burnet
    Pages 191-199
  15. Macfarlane Burnet
    Pages 201-212
  16. Macfarlane Burnet
    Pages 213-222
  17. Back Matter
    Pages 223-243

About this book

Introduction

In 1957 or thereabouts I became impressed with how immunity could be looked at as a process of Darwinian selection amongst the circulating lymphoid cells of the body. The clonal selection theory which grew out of this has been generally accepted in principle by immunologists, but I do not feel that its full implications in relation to pathology have yet been widely realized. In a previous book, Immunological Surveillance, I have tried to apply the approach to cancer immunity. This is a basically similar attempt to look at auto-immune disease from the same Darwinian point of view. Anyone who attempts to produce acceptable general statements about complex biological and clinical phenomena must have a certain sense of guilt. No biological phenomenon can ever be completely, or even adequately, described. There can, at best, only be a progressive improvement in the acceptability, the intellectual elegance, or the practical usefulness of the working generalizations that can be produced. Any attempt to write at this interpretative level can easily be brushed aside as superficial, unnecessary, and liable to be proved wrong or irrelevant by new developments. It is anathema to many good professional scientists and their objections are real enough.

Keywords

immunity

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-011-8095-5
  • Copyright Information Springer Science+Business Media B.V. 1972
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-011-8097-9
  • Online ISBN 978-94-011-8095-5
  • Buy this book on publisher's site