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Influenza Models

Prospects for Development and Use

  • Editors
  • Philip Selby

Table of contents

  1. Front Matter
    Pages 1-11
  2. Philip Selby
    Pages 13-14
  3. Paul Fine
    Pages 15-85
  4. C. H. Stuart-Harris, J. W. G. Smith
    Pages 87-123
  5. N. T. J. Bailey, C. C. Spicer, L. P. Smith, K. Choi
    Pages 125-157
  6. L. R. Elveback, N. T. J. Bailey
    Pages 159-176
  7. N. T. J. Bailey, D. A. J. Tyrrell
    Pages 177-186
  8. P. E. M. Fine, L. R. Elveback
    Pages 187-200
  9. P. Haggett, G. F. Pyle, K. Choi
    Pages 201-230
  10. L. R. Elveback, J. W. G. Smith
    Pages 231-250
  11. Philip Selby
    Pages 251-256
  12. Back Matter
    Pages 257-259

About this book

Introduction

Kilbourne (1973) described the student of influenza as "continually looking back over his shoulder and asking 'what happened?', in the hope that understanding of past events will alert him to the catastrophies ofthe future". Experience suggests the futility of such a hope, since the most predictable feature of influenza is its unpredictability. Nonetheless, the stubborn viabil ity of this hope is strongly affirmed by the many attempts, described and discussed in this volume, to develop a useful and practical representation of influenza virus behavior. I hasten to add, however, that the desired model has yet to be perfected. The existence and usefulness of animal models of infectious diseases of man are well documented. Reproduction of disease by infecting an experimental animal satisfies the third of Koch's four postulates to establish proof of disease causation by a specific bacterium. Animal models also have been extremely useful in studies of the pathogenesis, immunoprophylaxis, and specific therapy of several important diseases, ineluding (with only modest success) influenza. Development of such a model is simple, at least in concept. and can be achieved by one or only a few scientists.

Keywords

infectious infectious disease infectious diseases vaccine virus

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-011-8050-4
  • Copyright Information Springer Science+Business Media B.V. 1982
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-011-8052-8
  • Online ISBN 978-94-011-8050-4
  • Buy this book on publisher's site