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Microbial Transformations of Steroids

  • Authors
  • Alois Čapek
  • Oldřich Hanč
  • Milan Tadra

Part of the Biologia Et Industria book series (CBA)

Table of contents

  1. Front Matter
    Pages 1-10
  2. Alois Čapek, Oldřich Hanč, Milan Tadra
    Pages 11-17
  3. Alois Čapek, Oldřich Hanč, Milan Tadra
    Pages 18-40
  4. Alois Čapek, Oldřich Hanč, Milan Tadra
    Pages 41-54
  5. Alois Čapek, Oldřich Hanč, Milan Tadra
    Pages 55-64
  6. Alois Čapek, Oldřich Hanč, Milan Tadra
    Pages 65-68
  7. Alois Čapek, Oldřich Hanč, Milan Tadra
    Pages 69-77
  8. Alois Čapek, Oldřich Hanč, Milan Tadra
    Pages 78-109
  9. Alois Čapek, Oldřich Hanč, Milan Tadra
    Pages 110-116
  10. Alois Čapek, Oldřich Hanč, Milan Tadra
    Pages 117-128
  11. Alois Čapek, Oldřich Hanč, Milan Tadra
    Pages 129-146
  12. Alois Čapek, Oldřich Hanč, Milan Tadra
    Pages 147-180
  13. Alois Čapek, Oldřich Hanč, Milan Tadra
    Pages 181-233
  14. Back Matter
    Pages 235-250

About this book

Introduction

Fundamental studies of steroid compounds have begun approximately thirty years ago with the solution of structures of cholesterol and bile acids. This field has been receiving more attention when the structures of the principal steroid hormones, aglycones of heart glycosides, sapogenins, steroid alkaloids, toad poisons have been established. An intensive interest in these derivatives of cyc1opentanoperhydrophe­ nanthrene was determined especially by practical viewpoints, notably by attempts to prepare by synthetical economical procedures a series of steroid hormones and their biologically active derivatives, further by theoretical viewpoints. Biochemistry of steroids was developing in its beginnings by studies of meta­ bolites of steroid hormones in animal organism and soon has brought a number of practical results that could be used also in medical diagnostics. Considerably later, the metabolism of steroid compounds was followed also in microorganisms, again in connection with the practical problem to aid to economical syntheses of some steroid hormones. Two names are of primary importance for the pioneer works in microbial transformations of steroids, that of the Italian worker L. MAMOLI who first realized the microbial biosynthesis of testosterone from dehydroepiandro­ sterone, and of the American chemist and microbiologist D. H. PETERSON, who has contributed by his fundamental experiments in microbial hydroxylation of steroids to the position eleven, especially to the synthesis of cortisone. Microbial transforma­ tions of steroids nowadays offer a valuable tool in the preparation of series otherwise difficultly accessible steroid compounds.

Keywords

alkaloids biochemistry biological biosynthesis chemistry experiment metabolism microorganism solution structure synthesis

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-011-7603-3
  • Copyright Information Springer Science+Business Media B.V. 1966
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-011-7605-7
  • Online ISBN 978-94-011-7603-3
  • Buy this book on publisher's site